Research paperModeling the dopaminergic nerve terminal
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Non-linear stochastic model for dopamine cycle
2023, Chaos, Solitons and FractalsSpontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase
2022, NeuropharmacologyCitation Excerpt :However, these results could also be explained by distinct TH conformations in the homotetramer where a single DA binding site presents different KD values in each monomer (Tekin et al., 2014). Computational analysis have indicated the potential importance of feedback inhibition for dopaminergic neurotransmission (Justice et al., 1988; Wallace, 2007). Its experimental study is difficult due to the presence of indeterminate amounts of endogenous DA bound to TH in vivo.
Low-cost, thin-film, mass-manufacturable carbon electrodes for detection of the neurotransmitter dopamine
2020, BioelectrochemistryCitation Excerpt :Extracellular DA has been shown to affect postsynaptic neurons in the striatum in the brain [33] with current estimated concentrations of DA in the range of 5 to 50 nM. However, the synaptic concentration of DA is a function of different processes including release from terminals, metabolism and cellular uptake [34], and since release and uptake occur over rapid timescales, regulation of DA is a transient event and therefore the measurement time to obtain an accurate DA concentration for in vivo studies would be a critical factor for consideration. However, if estimates of DA concentration in the range of 5–50 nM are accurate as far as a rat model is concerned [33], then sensitivity down to tens of pM in solution as shown in this study should be suitable for physiological DA detection.
Neurobiological model of stimulated dopamine neurotransmission to interpret fast-scan cyclic voltammetry data
2015, Brain ResearchCitation Excerpt :The stimulating electrode was then lowered 100 μm every 10 min until the summed signal amplitude of the two electrodes began to decrease, at which point experimental data was collected for the FSCV studies. Because prolonged stimulation durations affect the refractory time interval necessary to reproduce a stimulated DA response (Justice et al., 1988), our studies utilized a conservative interval period between stimulations to facilitate attainment of reproducible signals. Thus, for stimulations of 1 s, 2 s, 3 s, 5 s, 10 s durations we waited 5, 10, 15, 15, and 20 min until the next stimulation, respectively.
Twenty years of dopamine research: Individual differences in the response of accumbal dopamine to environmental and pharmacological challenges
2008, European Journal of PharmacologyCitation Excerpt :Based on the level of dopamine fluorescence, the turn-over rate of dopamine and the sensitivity to dopamine depleting drugs, the diffuse compartment of dopamine was categorised as the alpha-methyl-para-tyrosine-sensitive, newly-synthesised pool whereas the dotted compartment of dopamine was categorised as the reserpine-sensitive, storage pool (Cools and Van Rossum, 1976; Cools, 1977; Cools and Van Rossum, 1980). Various models on dopamine release have been developed in the past 20 years (McMillen et al., 1980; Schoemaker and Nickolson, 1983; Justice et al., 1988; Leviel et al., 1989; Arbuthnott et al., 1990; Westerink, 2006). Numerous studies have demonstated that dopamine is released from both alpha-methyl-para-tyrosine-sensitive and from reserpine-sensitive pools.