The effects of Chronic Hypoxia on the pharmacological responsiveness of the pulmonary artery
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2017, Poultry ScienceCitation Excerpt :In high altitude conditions, low partial pressure of O2 results in an increase in physiological dead space within the bird's parabronchi, which further aggravates the hypoxic situation. Chronic hypoxia is a major contributor to vasoconstriction, pulmonary vasculature remodeling, increased vascular resistance, and right ventricular hypertrophy (Peacock et al., 1989; Karamsetty et al., 1995; Wideman et al., 1997; Raj and Shimoda, 2002). Therefore, given the roles of AGTR1 and UTS2D in hypoxia and vasoconstriction, the two genes are strong candidates for the heritable, polygenic trait of ascites.
Endothelial hyperpolarizing factor increases acetylcholine-induced vasodilatation in pulmonary hypertensive broilers arterial rings
2012, Research in Veterinary ScienceCitation Excerpt :The pathological findings in PAH in broiler chickens are similar to those reported in PAH in humans, and, therefore, possibly the broiler chicken can be used as a model in this context. The morphological changes in PAH includes thickening of the medial layer of pulmonary blood vessels (Karamsetty et al., 1993) and nowadays, it is quite clear that molecules produced in the endothelium are partly responsible for smooth muscle contraction and growth of the medial layer of the pulmonary arterial tree, when the balance of endothelial produced contractors and dilators is disrupted which leads to endothelial malfunction (Adnot et al., 1991; Budhiraja et al., 2004; Thorin and Webb, 2009). In previous studies, endothelin-1 (ET-1), an important vasoconstrictor, was found to be upregulated in susceptible chickens (Gomez et al., 2007).
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