Pokeweed antiviral protein: Ribosome inactivation and therapeutic applications
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Advances and prospects in biogenic substances against plant virus: A review
2017, Pesticide Biochemistry and PhysiologyCitation Excerpt :It is the main antiviral-active constituent from Phytolacca americana L., which exhibits a broad spectrum antiviral activity against TMV, poliovirus, herpes simplex virus (HSV), influenza virus, cytomegalovirus and human immunodeficiency virus (HIV) and so on. It can effectively inhibit replication of viruses at concentrations which do not suppress protein synthesis of the host cells [37–43]. Other plants in which the anti-plant-virus effective compounds are proteins include Chenopodium amaranticolor, and Mirabilis jalapa L. (see Table 1).
Depurination of brome mosaic virus RNA3 in vivo results in translation-dependent accelerated degradation of the viral RNA
2008, Journal of Biological ChemistryIsolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa
2007, Antiviral ResearchRibosomal Protein L3: Gatekeeper to the A Site
2007, Molecular CellCitation Excerpt :Regions of two important rRNA helical structures are also anchored on this central extension (also called the “W finger” after the tryptophan residue): helix 95, and the structure formed by helices 90–92. Helix 95 contains the sarcin/ricin loop (SRL), one of the key structures recognized by the translation elongation factors, and the target of ribosome-inactivating proteins such as ricin (reviewed in Irvin and Uckun [1992]). The helix 90–92 structure is important because it forms one side of the corridor along which the 3′ ends of aa-tRNAs slide during the process of accommodation (Sanbonmatsu et al., 2005).