Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents
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Cited by (199)
Tubulin degradation: Principles, agents, and applications
2023, Bioorganic ChemistryProgress of tubulin polymerization activity detection methods
2021, Bioorganic and Medicinal Chemistry LettersCitation Excerpt :Iodoacetamide is an important sulfhydryl modification reagent for sulfhydryl alkylation.64 The iodoacetamide experiment is based on iodoacetamide crosslinking the Cys-239 and Cys-354 residues on the colchicine binding site of β-tubulin, alkylating the sulfhydryl group of cysteine, occupying the colchicine binding site, and covalently binding with β-tubulin to form the adduct of EBI and β-tubulin.65,66 The migration rate of adduct was faster than that of β-tubulin, and the additive band appeared at the position of smaller molecular weight in the result of western blotting.66,67
Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin
2021, Current Biology
Copyright © 1991 Published by Elsevier Inc.