The psychopharmacology of 5-HT3 receptors
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2019, Behavioural Brain ResearchCitation Excerpt :Interestingly, the dendritic tree of CCK + basket cells has an average length of 6300 μ and penetrates all layers [306]. CCK + INs received of serotonergic [307] cholinergic [308] subcortical projection neurons and additionally GABAergic projection from local CalR + INs [308]. CCK + , like PV + INs, make synapses on pyramidal neurons and act on CCKBRs to increase extracellular levels of GABA, which then acts on GABABRs to decrease IPSC amplitude [309].
Serotonin receptors in depression and anxiety: Insights from animal studies
2018, Life SciencesCitation Excerpt :Many preclinical data indicated the 5-HT3 receptor as a potential target in the treatment of anxiety (Table 6, reviewed in [174]). Behavioral studies demonstrated that 5-HT3 receptor antagonists were effective in rodent anxiety models, e.g., social interaction test in rats or light/dark exploration test in mice, secondary to the limbic hyperactivity response blockade (reviewed in [175]). The atypical 5-HT3 receptor antagonist, VA21B7, showed anxiolytic-like activity in the elevated plus maze and punished-drinking in rats [176].
Tropisetron upregulates cannabinoid CB <inf>1</inf> receptors in cerebellar granule cells: Possible involvement of calcineurin
2011, Brain ResearchCitation Excerpt :They also indicated that classical calcineurin inhibitors such as cyclosporine or tacrolimus (FK506) upregulate CB1 receptor expression (Kramer et al., 2003). Regarding the fact that tropisetron and CB1 receptor agonists share various pharmacological effects including anti-emetic (Scuderi, 2001) analgesic (Riering et al., 2004), anxiolytic (Costall et al., 1990; Lecrubier et al., 1993) anti-inflammatory (Schneider et al., 2004; Seidel et al., 2004) properties and taking into account the ability of calcineurin to control CB1 expression (Kramer et al., 2003), we aimed to investigate possible effects of tropisetron on calcineurin activity and CB1 receptor expression as well as its secondary messenger, cAMP, content in primary cerebral granule neuron cultures. Their high content of calcineurin (Klee et al., 1998) makes cerebellar granule cells ideal for investigating effects of tropisetron on calcineurin activity.
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2011, Pharmacology Biochemistry and BehaviorThe 5-HT<inf>3</inf> receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats
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