The central neuropharmcology of psychotropic cannabinoids
References (294)
- et al.
Delta-1-tetrahydrocannabinol derivative enhances excitatory synaptic potentials through a presynaptic mechanism in crayfish neuromuscular junction
Comp. Biochem. Physiol.
(1977) - et al.
Osmotic fragility of liposomes as affected by anti-hemolytic compounds
Biochim. Biophys. Acta
(1974) - et al.
Effect of tetrahydrocannabinols on brain acetylcholine
Brain Res.
(1974) - et al.
The interaction of hashish compounds with planar lipid bilayer membranes (BLM)
Biochem. Pharmac.
(1976) - et al.
The effect of hashish compounds of phospholipid phase transition
Biochim. Biophys. Acta
(1976) - et al.
Effect of delta-9-tetrahydrocannabinol on monoamine oxidase activity of rat tissues in vivo
Biochem. Pharmac.
(1975) - et al.
Differential effects produced by delta-1-tetrahydrocannabinol on lateral geniculate neurones
Neuropharmacology
(1973) - et al.
Delta-7-tetrahydrocannabinol, a non-psychotropic cannabinoid: structure activity considerations in the cannabinoid series
- et al.
Triglyceride/phospholipid partitioning and pharmacokinetics of some natural and semi-synthetic cannabinoids: further evidence for the involvement of specific receptors in the mediation of the psychotropic effects of delta-1-THC and delta-6-THC
- et al.
Biochemical effects and morphological changes in rat liver mitochondria exposed to delta-1-tetrahydrocannabinol
Biochim. Biophys. Acta
(1972)
Effects of cannabinoids on neurotransmitter receptors in the brain
Effects of delta-9-tetrahydrocannabinol on ATPases in mouse brain subcellular fractions
Life Sci.
Regional brain homovanillic acid following delta-9-tetrahydrocannabinol and cocaine
Brain Res.
Differential effects of a tetrahydrocannabinol and pentobarbital on cerebral cortical neurones
Neuropharmacology
Comparisons of the effects of delta-9-tetrahydrocannabinol, 11-hydroxy-delta-9-tetrahydrocannabinol and ethanol on the electrophysiological activity of the giant axon of the squid
Neuropharmacology
Lysis of rat liver lysosomes in vitro by delta-9-tetrahydrocannabinol
Biochem. Pharmac.
Alterations in the organization of phosphatidylcholine/cholesterol bilayers by tetrahydrocannabinol
J. Biol. Chem.
Prostaglandins and cannabis—VI. Release of arachidonic acid from HeLa cells by delta-1-tetrahydrocannabinol and other cannabinoids
Biochem. Pharmac.
The role of prostaglandins in the actions of the cannabinoids
Inhibition of prostaglandin E2 biosynthesis by delta-1-tetrahydrocannabinol
Prostaglandins
Prostaglandins and cannabis—II. Inhibition of biosynthesis by the naturally occurring cannabinoids
Biochem. Pharmac.
Inhibition of cholesterol esterases by delta-1-tetrahydrocannabinol
Life Sci.
Prostaglandins and cannabis—IX. Stimulation of prostaglandin E2 synthesis in human lung fibroblasts by delta-1-tetrahydrocannabinol
Biochem. Pharmac.
Prostaglandins and cannabis—XI. Inhibition of delta-1-tetrahydrocannabinol-induced hypotension by aspirin
Biochem. Pharmac.
Prostaglandins and cannabis—XIII. Cannabinoid-induced elevation of lipoxygenase products in mouse peritoneal macrophages
Biochem. Pharmac.
Prostaglandins and cannabis—XV. Comparison of enantiomeric cannabinoids in stimulating prostaglandin synthesis in fibroblasts
Life Sci.
Prostaglandins and cannabis—XVI. Antagonism of delta-1-tetrahydrocannabinol action by its metabolites
Biochem. Pharmac.
Stabilization of rat erythrocyte membrane by delta-1-tetrahydrocannabinol
Life Sci.
Effect of delta-1-tetrahydrocannabinol on ATPase activity of rat liver mitochondria
Biochem. Pharmac.
Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice
Eur. J. Pharmac.
The effects of delta-9-tetrahydrocannabinol injections to the nucleus accumbens on the locomotor activity of rats
Direct and pituitary-mediated effects of delta-9-THC and cannabinol on the testis
Pharmac. Biochem. Behav.
Effects of delta-9-tetrahydrocannabinol on the levels of cyclic adenosine 3′,5′-monophosphate in mouse brain
Biochem. Pharmac.
Effects of various psychotomimetic agents on the EEG and acetylcholine release from the cerebral cortex of brain-stem transected cats
Neuropharmacology
Marihuana and epilepsy: Paradoxical anticonvulsant and convulsant effects
Delta-9-THC and 17-beta-estradiol in hippocampus
Brain Res. Bull.
Physicochemical properties, solubility and protein binding of delta-9-tetrahydrocannabinol
J. Pharm. Sci.
Brain levels of delta-1-tetrahydrocannabinol and its metabolites in mice—Correlation with behaviour and the effect of the metabolic inhibitors SKF 525A and piperonyl butoxide
Biochem. Pharmac.
Blood and brain levels of delta-1-tetrahydrocannabinol in mice—The effect of 7-hydroxy-delta-1-tetrahydrocannabinol
Biochem. Pharmac.
Contribution of the metabolite 7-OH-delta-1-tetrahydrocannabinol towards the pharmacological activity of delta-1-tetrahydrocannabinol in mice
Biochem. Pharmac.
Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers
Pharmac. Rev.
The effects of delta-9-tetrahydrocannabinol on action potentials in the mollusc Aplysia
Can. J. Physiol. Pharmac.
Cannabis and central dopaminergic transmission: effect on receptor sensitivity and behavioral modulation
Res. Commun. Subst. Abuse
Pharmacokinetics and metabolism of delta-1-tetrahydrocannabinol and other cannabinoids with emphasis on man
Pharmac. Rev.
Effects of tetrahydrocannabinols on cyclic AMP levels in rat brain areas
Experientia
Acute effect of delta-1-tetrahydrocannabinol on the hypothalamo-pituitary-ovarian axis in the rat
Neuroendocrinology
Cannabinoids: Influence on neurotransmitter uptake in rat brain synaptosomes
J. Pharmac. Exp. Ther.
Action of delta-9-tetrahydrocannabinol on membrane-bound monoamine oxidase activity
Toxicol. Appl. Pharmac.
Dependence on tetrahydrocannabinol in rhesus monkeys
J. Pharmac. Exp. Ther.
Effect of delta-9-THC on the distribution uptake and release of catecholamine in rats
Rev. Can. Biol.
Cited by (130)
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
2023, European Journal of Medicinal ChemistryTreatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: Interlinking the endocannabinoid system
2023, Neurobiology and Physiology of the Endocannabinoid SystemCannabinoids and mitochondria
2021, Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial HealthCannabis Pharmacology: The Usual Suspects and a Few Promising Leads
2017, Advances in PharmacologyCitation Excerpt :Conversely, THC inhibits T-type calcium (Cav3) voltage-gated ion channels, potassium Kv1.2 voltage-gated ion channels, conductance in Na+ voltage-gated ion channels (−), and conductance in gap junctions between cells at concentrations between 1 and 10 μM. THC can also interact with a variety of enzymes such as phosphlipases, lysophosphatidylcholine acyl transferase, lipoxygenase, Na+-K+-ATPase, Mg2 +-ATPase, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C9, and monoamine oxidase activity (Evans, 1991; Pertwee, 1988; Pertwee & Cascio, 2014; Yamaori et al., 2012; Yamaori, Kushihara, Yamamoto, & Watanabe, 2010; Yamaori, Okamoto, Yamamoto, & Watanabe, 2011). The synaptic conversion of tyrosine to noradrenaline and dopamine (DA) is increased by THC while norepinephrine-induced melatonin biosynthesis is inhibited.
Neurosteroids and potential therapeutics: Focus on pregnenolone
2016, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Recently, our group discovered that PREG was capable of reducing central cannabinoid effects, which are mediated by the type-1 cannabinoid (CB1) receptor, the most abundant G protein coupled receptor (GPCR). CB1 receptor is expressed widely within the brain [140] and is the main target of the major psychoactive component of Cannabis sativa, delta-9 tetrahydrocannabinol (THC) [114]. We discovered that the inhibitory action of PREG on THC-mediated effects involved CB1 receptors.
CB1 Receptor-Mediated Signaling Mechanisms in the Deleterious Effects of Spice Abuse
2016, Neuropathology of Drug Addictions and Substance Misuse