Review articleImmunological characterization and functional importance of human heart mast cells
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2016, Translational ResearchCitation Excerpt :MCs also promote homeostasis by degrading certain endogenous toxic compounds such as endothelin 1 or neurotensin released in response to bacterial infection and bacterial toxins via their potent proteases. The presence of MCs has been documented in the human heart.5-8 MCs generally reside in the interstitial space between the cardiomyocytes and are often in close proximity to nerves,5,9,10 which may be relevant to the generation and progression of arrhythmias.
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2016, European Journal of Internal MedicineCitation Excerpt :These mediators are responsible for plasma extravasation and tissue edema, inflammation and leukocyte recruitment, bronchoconstriction and mucus secretion [15]. In heart tissues mast cells are abundant [16,17]: they preferentially locate at sites of coronary plaques [18,19] and might contribute to coronary artery thrombosis [5,20]. Upon mast cell degranulation, histamine is released thus promoting plaque disruption by increasing the arterial hemodynamic stress on the plaque, inducing vasospasm, or both [20,21].
The novel role of mast cells in the microenvironment of acute myocardial infarction
2011, Journal of Molecular and Cellular Cardiology