Multiple simultaneous determinations of hemodynamics and flow distribution in conscious rat
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Angiotensin converting enzyme inhibition improves cerebrovascular control during exercise in male rats with heart failure
2021, Respiratory Physiology and NeurobiologyCitation Excerpt :Thus, the impairments in cerebral BF in HF-rEF are not likely to be attributed to greater decreases in cerebral PaCO2 during exercise. Second, the cannulation of a carotid artery to administer radiolabeled microspheres could potentially have altered our cerebral BF measurements, however, Flaim et al. (1984) demonstrated that this specific procedure does not impact cerebral BF. Third, we did not measure circulating levels of Captopril or Ang II.
Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat
2020, Respiratory Physiology and NeurobiologyCitation Excerpt :This period of recovery was selected to avoid changes in tissue glycogen content as a result of the catheterization (Moore et al., 1988) that may impact running performance negatively. Additionally, the recovery time for all animals was equivalent to account for the possibility of the confounding effects of the anesthesia regimen (Lawson et al., 2001), although, importantly, it has been demonstrated that a window of 1–6 h of recovery after anesthesia elicits stable cardiac and circulatory dynamics, regional blood flow, arterial blood gases, and acid-base status in the awake unrestrained rat (Flaim et al., 1984; Poole et al., 2020). Following the completion of the exercise protocols and resting measurements, rats were anesthetized and euthanized with an overdose of sodium pentobarbital (≥100 mg/kg body wt.)
Intercostal muscle blood flow is elevated in old rats during submaximal exercise
2019, Respiratory Physiology and NeurobiologyCitation Excerpt :Both catheters were tunneled subcutaneously through the dorsal aspect of the cervical region and exteriorized through a puncture in the skin. The incisions were then closed, anesthesia was terminated, and the rats were given >90 min to recover (Flaim et al., 1984). Following recovery, each rat was placed on the motor-driven treadmill and the carotid artery catheter was connected to the pressure transducer (model P23ID, Gould Statham, Valley View, OH).
Cardiovascular research
2019, The Laboratory RatDietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise
2018, Respiratory Physiology and NeurobiologyCitation Excerpt :A second catheter was placed in the caudal (tail) artery for arterial blood sampling (Musch and Terrell, 1992). Both catheters were tunneled subcutaneously to the dorsal aspect of the neck, exteriorized, anesthesia was terminated, and the rats were given >60 min to recover (Flaim et al., 1984). Following the completion of the final experimental protocol and resting measurements, rats were anesthetized with pentobarbital sodium (>50 mg/kg body wt) via the right carotid artery catheter.
Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise
2017, Respiratory Physiology and NeurobiologyCitation Excerpt :Both catheters were tunneled subcutaneously through the dorsal aspect of the cervical region and exteriorized through a puncture in the skin. The incisions were then closed, anesthesia was terminated, and the rats were given >90 min to recover (Flaim et al., 1984). Following recovery, each rat was placed on the motor-driven treadmill and the carotid artery catheter was connected to the pressure transducer (model P23ID, Gould Statham, Valley View, OH).