Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis
References (2)
The estimation of basic organic compounds in biological material v. estimation by salt formation with methyl orange
J. Biol. Chem.
(1947)Biochemical effects of d-tetrandrine and thalicarpine
Biochem. Pharmacol.
(1976)
Cited by (38)
Phytocompounds as a source for the development of new drugs to treat respiratory viral infections
2023, Studies in Natural Products ChemistryThe biology and total syntheses of bisbenzylisoquinoline alkaloids
2021, Organic and Biomolecular ChemistryGene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
2021, Cell Chemical BiologyCitation Excerpt :Although tetrandrine (1) also considerably inhibited proliferation of RIL175 cells (IC50 9.1 μM), antiproliferative effects were markedly enhanced for SG-005 (2) and SG-094 (3) (IC50 2.4 and 3.7 μM, respectively). Tetrandrine (1) has serious deficiencies, which include its structural complexity and its toxicity (Jin et al., 2011; Li et al., 2019a; Qi et al., 2013; Tainlin et al., 1982; Yan et al., 2006). To cope with these limitations, we synthesized and characterized various analogs of the lead molecule.
Synthesis, biological evaluation and toxicity of novel tetrandrine analogues
2020, European Journal of Medicinal ChemistryCitation Excerpt :The plant bisbenzylisoquinoline alkaloid tetrandrine (1) has diverse pharmacological properties [3,4], including antiviral [5–8], anticancer [9,10], multidrug resistance reversing [11–15] and calcium channel blocking [6,16–18] activities, making this alkaloid an attractive drug candidate. Unfortunately, its clinical application is limited by its toxicity, mainly affecting liver and lungs [26–30]. Five diastereomeric pairs of novel analogues of tetrandrine and its natural diastereomer isotetrandrine, respectively, were synthesized and biologically evaluated with respect to their toxicity, their antiproliferative and multidrug resistance reversing activity.
A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine
2020, Organic and Biomolecular Chemistry