Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord

doi:10.1016/0143-4179(85)90006-X

Neuropeptides

Volume 6, Issue 4, July 1985, Pages 331-342

https://doi.org/10.1016/0143-4179(85)90006-X Get rights and content

Abstract

The autoradiographic distribution of mu, delta and kappa opioid binding sites was evaluated in various segments of the rat and guinea pig spinal cord. Mu opioid receptor binding sites are highly concentrated in the superficial layers of the dorsal horn (laminae II and III) in both species, without any marked gradient along the cord. Delta binding sites are somewhat concentrated in the superficial layers of the dorsal horn. However, delta binding sites are also present and evenly distributed in other areas of the gray matter. The highest density of delta sites is found in the cervical segment with only low levels in the lumbo-sacral region of the rat and guinea pig spinal cord. Kappa opioid binding sites are highly concentrated in the superficial layers of the dorsal horn of the spinal cord. Lower levels are seen in the rest of the gray matter with some enrichment in lamina X. Moreover, the lumbo-sacral portion of the spinal cord is enriched in kappa sites as compared to the cervical and thoracic segments. These data demonstrate the differential laminar distribution of mu, delta and kappa opioid binding sites in rat and guinea pig spinal cord.

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Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord

Abstract

Pain

Neuroscience

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Life Sci.

Life Sci.

Life Sci.

Life Sci.

Life Sci.

Brain Res.

Neuropeptides

Eur. J. Pharmacol.

Life Sci.

Neuropeptides

Life Sci.

Life Sci.

Life Sci.

Peptides

Brain Res.

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Exp. Neurol.