Cell
ArticleActivation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
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2022, Computers in Biology and MedicineCitation Excerpt :Cluster 1 encompassed 24 nodes and 222 edges with a score of 9.652. The seed node of this cluster is glycogen synthase kinase-3 beta (GSK3B), which acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling, regulation of transcription factors and microtubules, by phosphorylating and inactivating a batch of proteins, for instance, GYS1/GYS2, EIF2B, CTNNB1, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC, etc [48,49]. Cluster 2 contained 9 nodes and 58 edges with a score of 7.25.
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Present address: Department of Molecular and Cellular Biology, AMGEN Center 1900 Oak Terrace Lane, Thousand Oaks, California 91320.
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Present address: Institut fur Genetik and Toxikologie, Kernforschungszentrum Karlsruhe, D-7500 Karlsruhe, Federal Republic of Germany.