Cell
ArticleLinkage of prion protein and scrapie incubation time genes
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2018, Handbook of Clinical NeurologyCitation Excerpt :Prusiner (1982) introduced the term prion and Oesch et al. (1985) identified the cellular gene encoding the PrP. The PrP gene was then demonstrated to be the major factor controlling incubation time of disease (Dickinson et al., 1968; Carlson et al., 1986; Hunter et al., 1987; Westaway et al., 1987; Moore et al., 1998). Classic scrapie usually affects sheep around 3–5 years of age.
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