Article
Systemic injection of p-chloroamphetamine eliminates the effect of the 5-HT3 compounds on learning

https://doi.org/10.1016/0091-3057(95)02104-3Get rights and content

Abstract

There is evidence that 5-HT3 antagonists enhance learning and memory; however, their mechanisms of action are unknown. The aim of the present work was to investigate further the role of 5-HT3 receptors involved in learning, using the specific 5-HT3 agonist 1-(m-chlorophenyl)-biguanide (mCPBG) and the 5-HT3 antagonists ondansetron and tropisetron. p-Chloroamphetamine (PCA) pretreatment was used to determine whether pre- or postsynaptic 5-HT3 receptors are involved in learning. The posttraining intraperitoneal (IP) injection of each drug was analyzed on a lever-press response on autoshaping, which is an associative learning task. The results showed that mCPBG impaired retention of the conditioned response (CR), whereas tropisetron and ondansetron improved it. In other animals, PCA alone did not affect CR but was able to block the effects of the 5-HT3 ligands. The present data suggest that the actions of 5-HT3 compounds could be due to their interaction with presynaptic 5-HT3 receptors.

References (26)

  • M.W. Decker et al.

    The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory

    Synapse

    (1991)
  • A.J. Gower

    5-HT receptors and cognitive function

  • G.A. Higgins et al.

    Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats

    J. Pharmacol. Exp. Ther.

    (1993)
  • Cited by (34)

    • Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis

      2016, Neuroscience
      Citation Excerpt :

      Performance of 5-HTRs in various tasks could either be facilitating or disruptive (Roman and Marchetti, 1998; Meneses and Perez-Garcia, 2007). Our data are in agreement with the reports indicating that IP injection of m-CPBG, induced aversive learning deficit in the passive avoidance task (Rajan et al., 2011), also dose-dependently impaired short- and long-term memory in the autoshaping task (Meneses, 2007) and decreased the retention of the conditioned response (CR), in an associative learning task (Hong and Meneses, 1996). It was also reported that intra-CA3 injection of m-CPBG impaired aversive memory acquisition in a one-trial passive avoidance task (Nasehi et al., 2015a).

    • Serotonin/dopamine interaction in learning

      2008, Progress in Brain Research
      Citation Excerpt :

      However, an effect of these receptors on learning and memory has been reported. Post-training intraperitoneal administration of the agonist mCPBG impaired retention in autoshaping tests, whereas the antagonists tropisetron and ondansetron improved retention (Hong and Meneses, 1996; Meneses, 2007). Granisetron, another 5-HT3 receptor antagonist, induced deficiencies in spatial learning in a Morris water maze when it was infused intra-hippocampally 20 min before daily training without having any effect on visual discrimination (Naghdi and Harooni, 2005).

    View all citing articles on Scopus

    The receptor nomenclature used in this report is recommended by the Serotonin Club Nomenclature Committee (10). The research was supported by CONACYT Grant 4367-M9406.

    View full text