ArticleGR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test
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Serotonin 5-HT<inf>1A</inf> and 5-HT<inf>1B</inf> receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats
2020, Pharmacology Biochemistry and BehaviorCitation Excerpt :Although RU 24969 has a high affinity for both 5-HT1A and 5-HT1B receptors (Hoyer, 1991), studies using selective 5-HT antagonists alternately report that the RU 24969-induced locomotor activity of adult rats and mice is mediated exclusively by the 5-HT1A receptor (Aronsen et al., 2014; Kalkman, 1995), the 5-HT1B receptor (Chaouloff et al., 1999; Cheetham and Heal, 1993; Shanahan et al., 2009), or both (O'Neill and Parameswaran, 1997). It is interesting that studies examining this question have almost exclusively used the 5-HT1B/1D receptor antagonist GR 127935, while the role of 5-HT1A receptors has been assessed using WAY 100135, WAY 100635, and SDZ 216-525 (Aronsen et al., 2014; Chaouloff et al., 1999; Cheetham and Heal, 1993; Kalkman, 1995; O'Neill and Parameswaran, 1997; O'Neill et al., 1996; Shanahan et al., 2009). Although RU 24969 stimulates locomotor activity and/or patterned limb movements by as early as postnatal day (PD) 1 (Jackson and Kitchen, 1989; Pranzatelli, 1992), it is not known whether the 5-HT1A or 5-HT1B receptor subtype mediates RU 24969's actions during early ontogenetic periods.
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