Tolerance to oral and IP caffeine: Locomotor activity and pharmacokinetics
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2019, Drug and Alcohol DependenceCitation Excerpt :We established that caffeine increased the motivation to obtain sucrose and that this effect of caffeine was dose-dependent, with moderate doses (12.5 mg/kg) increasing motivation the most and lower (6.25 mg/kg) and higher (25 mg/kg) doses increasing motivation the least. Interestingly, the effect of caffeine tended to decline over daily repeated test sessions, resulting in a downward shift in the dose-response curve, which is consistent with previous studies showing tolerance to the psychomotor stimulant effects of caffeine under a repeated daily dosing protocol (Lau and Falk, 1994). Caffeine is available in multiple forms (e.g., beverages and pills), however, human consumption of caffeine for its psychoactive effect is dominated by beverages – complex vehicles that often include sugars or sweeteners (e.g., energy drinks) or to which fats, sugars, and sweeteners are commonly added (e.g., coffee, Reissig et al., 2009).
Caffeine triggers behavioral and neurochemical alterations in adolescent rats
2014, NeuroscienceCitation Excerpt :Considering that at the time of behavioral tasks caffeine were still present in the brains of adolescent rats, the lack of locomotor habituation during the second day in the open field of rats that consumed the highest caffeine concentration (1 mg/mL) could also be a reflection of the motor stimulant effects of caffeine due to the sustained blockade of A1 and A2A adenosine receptors within the CNS. In fact, the direct relationship between plasma caffeine concentrations and the magnitude of motor activation in adult rats has been found (Lau and Falk, 1994). In addition, pharmacokinetic studies revealed that following a single oral dose of caffeine (10 mg/kg) to 40-day-old male Sprague–Dawley rats, the average half-life of caffeine in the plasma is 120 min, and in the brain is 132 min (Latini et al., 1980).
Long-lasting resistance to haloperidol-induced catalepsy in male rats chronically treated with caffeine
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2007, Pharmacology Biochemistry and BehaviorCaffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy
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