Dizocilpine prevents the development of tolerance to the sedative effects of diazepam in rats
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Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain
2023, Neurobiology of DiseaseStudies on some neuropharmacological properties of Nevirapine in mice
2022, IBRO Neuroscience ReportsCitation Excerpt :In these tests, agents with stimulatory properties promotes exploratory activities while agents with sedative or angiogenic properties elicit a decrease in exploratory activities interpreted as a decrease in curiosity of the new environment (Abubakar and Haque, 2019; Ya’u et al., 2011). The open field is an acceptable model for evaluation of locomotor activity and other gross-behavioural effects of drugs (Amos et al., 2004; File and Fernandes, 1994; Hsieh et al., 1991). The model measures the exploratory/ locomotor which correlates with effects on the CNS in rodents (Morais et al., 1998).
Biological behavior of 1, 4-benzodiazepines and 1, 4-benzothiazepines
2022, Benzodiazepine-Based Drug DiscoveryPerampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats
2018, Epilepsy ResearchCitation Excerpt :Considering that also PER does not modify clobazam plasma levels and benzodiazepine binding, we suppose that the increased and prolonged effects of clobazam induced by PER concomitant treatment might be due to a role of AMPA receptors in the development of clobazam tolerance. This is in agreement with other studies demonstrating that other NMDA or AMPA receptor antagonists, at a low dose that did not possess anticonvulsant effects, were able to block tolerance development to some barbiturates (Khanna et al., 1998a,b) and diazepam (Dunworth and Stephens, 1998; File and Fernandes, 1994). Therefore, our results suggest that PER combination with clobazam or other benzodiazepines might not only be efficacious but also worth in the long term considering the possible development of tolerance.
Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α<inf>1</inf> GABA<inf>A</inf> receptors
2013, European NeuropsychopharmacologyCitation Excerpt :Actually, the latency results revealed a reduction of the impairing effects of DZP during the last two days of acquisition. A phenomenon of rapid tolerance after three (File and Fernandes, 1994), or only one dose (Khanna et al., 1998) of a BZ has been described for some behavioral outputs. However, McNamara and Skelton (1997) found that tolerance to amnesic effects in the water maze did not develop even after 15 days of DZP pretreatment, demonstrating that the present results cannot be reflective of a genuine tolerance.