Hypothalamic infusion of the agonist, DOI, prevents the inhibitory actions of the 5-HT1A agonist, 8-OH-DPAT, on lordosis behavior
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Cited by (29)
Comparison of female Fischer and Sprague-Dawley rats in the response to ketanserin
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :In contrast, agonists that act primarily on 5-HT2 or 5-HT3 receptors facilitate lordosis behavior in female rats with relatively low sexual receptivity (Mendelson and Gorzalka, 1985; Wolf et al., 1999; Wolf et al., 1998). A potentially beneficial effect of 5-HT2 and 5-HT3 receptors is inferred from observations that 5-HT2 and 5-HT3 receptor agonists protect against the lordosis-inhibiting effects of 5-HT1A receptor agonists (Maswood et al., 1998; Uphouse et al., 1994) and that 5-HT2 and 5-HT3 receptor antagonists inhibit lordosis behavior (Gonzalez et al., 1997; Maswood et al., 1997). Therefore, drugs which lead to generalized increases in extracellular 5-HT could disrupt the balance between activation of 5-HT receptors that inhibit and those that facilitate lordosis behavior.
Role of 5-HT<inf>1A</inf> receptors in fluoxetine-induced lordosis inhibition
2010, Hormones and BehaviorSerotonin and Sexual Behavior
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :Endogenous 5-HT acts upon all available 5-HT receptors so that the net behavioral outcome is a composite of all the information received from receptor activation. For example, while 8-OH-DPAT inhibits lordosis behavior following infusion into the VMN, co-infusion with either 5-HT2 receptor agonists or a 5-HT3 receptor agonist can prevent the lordosis inhibition (Uphouse et al., 1994b; Maswood et al., 1998) Similarly, the 5-HT2A/2C receptor agonist DOI can attenuate the reduction in lordosis behavior initiated by the 5-HT3 receptor antagonist, tropisetron (Maswood et al., 1998). Therefore, composite effects of the individual receptors are likely to provide important clues as to how the endogenous system is actually functioning.
Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist, GR 127935, on lordosis behavior
2009, Hormones and BehaviorThe PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior
2007, Behavioural Brain ResearchSerotonin receptor involvement in effects of restraint on female rat lordosis behavior
2007, Pharmacology Biochemistry and Behavior
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