Hyperactivity in the offspring of nicotine-treated rats: Role of the mesolimbic and nigrostriatal dopaminergic pathways
References (33)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Biochem.
(1976)- et al.
Soft drug use prior to and during pregnancy: A comparison of samples over a four year period
Drug Alcohol Depend.
(1984) - et al.
Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems
Pharmacol. Biochem. Behav.
(1989) - et al.
A rapid method for the dissection of the rat brain
Pharmacol. Biochem. Behav.
(1980) - et al.
Cigarette smoking: Carboxyhemoglobin, plasma nicotine and thiocyanate vs. self-reported smoking data and cardiovascular disease
J. Chron. Dis.
(1983) - et al.
Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
Eur. J. Pharmacol.
(1986) - et al.
Improved gas chromatographic method for the determination of nicotine and conitine in biologic fluids
J. Chromatogr.
(1981) - et al.
Nicotine-induced sensitization to ambulatory stimulant effect produced by daily administration into the ventral tegmental area and nucleus accumbens in rats
Life Sci.
(1992) - et al.
Action of nicotine on accumbens dopamine and attenuation with repeated administration
Eur. J. Pharmacol.
(1989) - et al.
Ligand: A versatile computerized approach for characterization of ligand-binding systems
Anal. Biochem.
(1980)
Nicotine administration to rats: Methodological considerations
Life Sci.
(1987)
Locomotion induced by ventral tegmental microinjections of a nicotinic agonist
Pharmacol. Biochem. Behav.
(1990)
A simultaneous single isotope radioenzymatic assay of plasma norepinephrine and dopamine
Life Sci.
(1977)
A new device for monitoring early motor development: Prenatal nicotine-induced changes
Pharmacol. Biochem. Behav.
(1988)
Comparison of drinking and smoking patterns during smoking over a six years interval
Am. J. Obstet. Gynecol.
(1983)
Biochemical and pharmacological aspects of attention deficit disorder
Cited by (93)
Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress
2019, Brain Research BulletinExamination of the Gateway Hypothesis in a rat model
2019, Pharmacology Biochemistry and BehaviorDevelopmental neurotoxicity of nicotine and tobacco
2018, Handbook of Developmental NeurotoxicologyPhysical, behavioral, and cognitive effects of prenatal tobacco and postnatal secondhand smoke exposure
2014, Current Problems in Pediatric and Adolescent Health CareCitation Excerpt :Animal studies have shown that prenatal exposure to nicotine causes increased motor activity, hyperactivity, and problems with attention, memory, and learning.199,200 One such study found a dose-dependent relationship between levels of nicotine exposure and “stimulation of locomotor activity in offspring,” reporting “involvement of both mesolimbic and nigrostriatal dopaminergic pathways.”200 SHS exposure in the perinatal period is sufficient to raise levels of nicotine to concentrations great enough to alter normal neurodevelopment.201
- 1
Present address: Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Philadelphia, PA 19104.
- 2
To whom requests for reprints should be addressed.
Copyright © 1993 Published by Elsevier Inc.