Chronic stress induces strain-dependent sensitization to the behavioral effects of amphetamine in the mouse

doi:10.1016/0091-3057(92)90638-V

Pharmacology Biochemistry and Behavior

Volume 43, Issue 1, September 1992, Pages 53-60

https://doi.org/10.1016/0091-3057(92)90638-V Get rights and content

Abstract

Following 10 days of daily restraint stress, sensitization developed to the stimulatory effect of amphetamine on locomotion in DBA/2 but not in C57BL/6 mice tested 24 h after the last stressful experience regardless of their being naive or habituated to the test cages. Saline-injected C57BL/6 mice, however, showed an increase of locomotion 24 h after chronic stress treatment. Chronically stressed mice of the two strains did not exhibit any alteration of dopamine and metabolites (3-4-dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine) levels in the frontal cortex, caudatus putamen, or nucleus accumbens septi, thus ruling out that stress-induced alteration of basal dopamine metabolism affected the behavioral response to amphetamine challenging in DBA/2 mice. Ten daily amphetamine injections (5 mg/kg) did not significantly modify the behavioral response to amphetamine in either strain of mice tested 24 h after the end of the chronic treatment and did not increase locomotion in saline-injected C57BL/6 mice. Finally, chronically stressed hybrids B6D2F1 did not show sensitization to the locomotor effects of amphetamine, suggesting a dominant mode of inheritance in the response to chronic stress of the C57BL/6 strain.

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¹: Present address: Department of Psychology, Concordia University, 1455 de Maisonneuve, Montreal, Quebec, Canada H3G 1M8

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Chronic stress induces strain-dependent sensitization to the behavioral effects of amphetamine in the mouse

Abstract

Physiol. Behav.

Brain Res.

Brain Res.

Behav. Neural. Biol.

Life Sci.

Brain Res.

Behav. Brain Res.

Brain Res.

Neuroscience

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Brain Res.

Eur. J. Pharmacol.

Brain Res.

Neurosci. Biobehav. Rev.

Eur. J. Pharmacol.

Life Sci.