Brief communicationPotentiation of cocaine's discriminative effects by caffeine: A time-effect analysis☆
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Behavioral interaction between cocaine and caffeine: A drug discrimination analysis in rats
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Cited by (55)
The drug discrimination assay: Interpretative value of partial generalization for drug schedule control actions
2018, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :Thirty-two chambers were used and housed within two security-controlled, video monitored, key-card access rooms of the test facility. Details of the training and test sessions are similar to those previously described elsewhere (Gauvin, Criado, Moore, & Holloway, 1990; Gauvin, Harland, Michaelis, & Holloway, 1989; Harland et al., 1989). Three groups of 32 rats were trained to discriminate between drug comparators or vehicle administered prior to the training sessions in daily 20–30 min sessions, under a FR10 schedule of food reinforcement.
Cocaine Addiction and Adenosine A1 and A2A Receptors
2017, The Neuroscience of Cocaine: Mechanisms and TreatmentAbuse liability assessment of hydrocodone under current draft regulatory guidelines
2015, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :The total drug intake induced by all four drugs demonstrated a linear monotonic function when plotted as a function of the tested doses. The dashed line in the cocaine dose-effect function shows the typical training dose used in standard cocaine 2-choice drug discrimination studies, which is based on the interoceptive properties of the drug (Gauvin et al., 1989, 1990; Harland et al., 1989). Rats self-administering iv cocaine titrated their drug intake to a cumulative dose that was clearly above an equivalent dose of ip administered cocaine required to establish discriminative stimulus control in rats.
Anti-aggressive effect elicited by coca-paste in isolation-induced aggression of male rats: Influence of accumbal dopamine and cortical serotonin
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :This result suggests that the interaction between cocaine and caffeine could be responsible for the difference observed on the latency to first attack in residents treated with CP and cocaine. Actually, it was demonstrated that caffeine can potentiate the action of cocaine on rewarding and stimulant effect (Bedingfield et al., 1998; Gauvin et al., 1990; Horger et al., 1991; López-Hill et al., 2011; Misra et al., 1986; Morelli and Simola, 2011). However, all these evidences indicate that caffeine, at certain doses, can enhance the actions of cocaine (Cauli and Morellia, 2005; Ferré, 2010; Palmour et al., 1989) rather than diminishing them.
Caffeine-induced taste aversions in Lewis and Fischer rat strains: Differential sensitivity to the aversive effects of drugs
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Work from our laboratory and others have suggested that cocaine's aversive effects may be mediated via its activity as a NET (norepinephrine transporter) inhibitor (Freeman et al., 2005, 2008; Serafine and Riley, 2009) by which it increases the overall levels of NE. Although caffeine has no effects on NET, acting instead as an adenosine antagonist (for review see Nehlig, 1999; also see Bedingfield et al., 1998), it is a CNS stimulant whose stimulus effects partially generalize to those of cocaine (see Gauvin et al., 1990). Interestingly, Geist and Ettenberg (1997) have reported that rats given cocaine in a goal box display an approach–avoidance response after conditioning.
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This research was supported by NIDA grant DA04444 to F.A. Holloway.