Variation of nicotinic binding sites among inbred strains
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2016, Neuroscience LettersCitation Excerpt :Thus our data confirms other studies that knockout of the α7nAChR does not impair LTP in adult C57 mice [20,21,41], although LTP impairment was noted in aged α7 KO mice on this background [41]. As mentioned above, WT Chrna7 gene expression is approximately 15% higher in C3H than in C57 [19]. However, other differentially-expressed genes between these two strains might also account for plasticity differences in WT animals, as well as for differential impacts and compensatory and/or adaptive mechanisms in α7 KO animals.
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