Self-administration of nalbuphine, butorphanol and pentazocine by morphine post-addict rats☆
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Cited by (23)
Evaluating the abuse potential of psychedelic drugs as part of the safety pharmacology assessment for medical use in humans
2018, NeuropharmacologyCitation Excerpt :The data also indicate that ketamine is the best of the non-competitive NMDA antagonists to be used as a Reference Comparator in these studies. Turning to the κ-opioid agonists, racemic pentazocine has been reported to maintain self-administration in rats (Lahti and Collins, 1982; Yoshimura et al., 1984), in morphine-addicted rats (Steinfels et al., 1982) and to substitute for morphine in rat IVSA (Nishida et al., 1989). In primate IVSA experiments, (±)-pentazocine substituted for codeine (Hoffmeister, 1988) and cocaine (Aigner and Balster, 1979) in monkeys and for cocaine in baboons (Lukas et al., 1986). (
Utility of Intracranial Self-Stimulation in the Assessment of the Abuse Liability of New Pharmaceuticals
2015, Nonclinical Assessment of Abuse Potential for New PharmaceuticalsThe predictive validity of the rat self-administration model for abuse liability
2011, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, overall changes in subjective-effects following levallorphan treatment were considered quite distinct from those of other narcotic analgesics (Jasinski et al., 1967), highlighting a limitation of using solely reports of positive subjective-effects as a clinical indicator of abuse liability. For drugs acting at both μ- and κ-opioid receptors, self-administration in rats was reported for butorphanol, nalbuphine, and pentazocine (Nishida et al., 1989; Steinfels et al., 1982). These drugs also produced positive subjective-effects in humans (Mello et al., 2005; Walsh et al., 2001; Zacny et al., 1997, 1998), but were assigned with a lower scheduling status than the aforementioned μ-agonists (typically schedule III–IV).
Butorphanol increases food-reinforced operant responding in satiated rats
1994, Pharmacology, Biochemistry and BehaviorEffect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm
1993, Pharmacology, Biochemistry and BehaviorOpiate dependence alters central reward of nalbuphine or pentazocine plus tripelennamine
1989, European Journal of Pharmacology
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Supported by NIDA grant DA-01050. A preliminary report of this study appeared in NIDA Research Monograph 34: Problems of Drug Dependence 1980, edited by L.S. Harris, pp. 138–144.
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Present address: Princeton University, Department of Psychology, Princeton, NJ 08540.