Theoretical reviewDiscriminative stimulus properties of narcotic analgesic drugs☆,☆☆
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2015, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :According to Shannon and Holtzman (1976), the property of morphine which enables it to function as a discriminative stimulus in the rat is analogous to the component of action of morphine responsible for producing the subjective effects in man. For opiates, there is a high correspondence between drugs that exert morphine-like discriminative effects in rats and those that evoke morphine-like subjective reports in humans (Colpaert, 1978; Shannon & Holtzman, 1977). Inasmuch as the subjective effects of opioids play an important role in their relatively high abuse potential (i.e. Fraser, 1968a,b; Jasinski, 1977), discrimination procedures provide a laboratory model in which to assess the opiate-like abuse potential of other NCEs (cf. Sannerud & Young, 1987).
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2009, Pharmacology Biochemistry and BehaviorThe hallucinogen derived from Salvia divinorum, salvinorin A, has κ-opioid agonist discriminative stimulus effects in rats
2007, NeuropharmacologyCitation Excerpt :Another aspect of the salvinorin A precipitated changes to bar press rates warrants mention because, in the pilot segment of our investigations, non-specific motor impairment (e.g., motor incoordination, motor depression, catalepsy) was specified for naïve rats that received salvinorin A injections in the 3–10 mg/kg dosing range. Since a systematic response rate decrement was not concluded during salvinorin A drug discriminating sessions, the possibility remains open that discordant motor effects, in discriminating relative to naïve rats, are reflecting cross-tolerance (Colpaert, 1978). If acceptance is granted for this interpretation, then the analyst asserts that animals receiving daily doses of U-69593 may manifest tolerance to the motor sedative effects of many κ-opioid receptor agonists.
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2006, Stress and Addiction: Biological and Psychological MechanismsWithdrawal, tolerance, and sensitization to dopamine mediated interoceptive cues in rats trained on a three-lever drug-discrimination task
2005, Pharmacology Biochemistry and Behavior
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Paper presented at the First International Symposium on Drugs as Discriminative Stimuli; July 3–5, 1978, Beerse, Belgium.
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The preparation of this paper as well as part of the author's published and newly reported studies in this area were supported by grants from the I.W.O.N.L.