Elsevier

Pharmacology Biochemistry and Behavior

Volume 3, Issue 6, November–December 1975, Pages 1055-1061
Pharmacology Biochemistry and Behavior

Drug-induced reinstatement of extinguished self-administration behavior in monkeys,☆☆,

https://doi.org/10.1016/0091-3057(75)90016-7Get rights and content

Abstract

Responding was established in squirrel monkeys under a modified progressive ratio schedule of IV d-amphetamine or cocaine self-administration. Substitution of saline for the drug solutions resulted in extinction of the self-administration behavior. IV injections of certain doses of d-amphetamine or cocaine, immediately prior to test sessions in which response-contingent saline infusions were delivered, reinstated the rate and pattern of responding observed during sessions in which drug was self-administered. Presession IV injections of several doses of pentobarbital or chlorpromazine failed to consistently reinstate responding. These results were interpreted in terms of the discriminative control of drug self-administration behavior by the current drug state of the subject.

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Supported by grant MT-3073 from the Medical Research Council of Canada to Dr. R. Stretch.

☆☆

We thank Andrea Gerber, Elizabeth Lane, and Les Schauss for technical assistance, and Drs. E. D. Olfert and F. M. Loew for veterinary services. Supplies of drugs were generously provided by Smith, Kline and French (d-amphetamine), May and Baker (cocaine and pentobarbital), and Poulenc (chlorpromazine).

Reprints may be obtained from G. Gerber, Department of Psychology, Sir George Williams University, 1455 deMaisonneuve Blvd. W., Montreal, Quebec H3G 1M8, Canada.

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