Drug-induced reinstatement of extinguished self-administration behavior in monkeys☆,☆☆,★
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Cited by (153)
Central GLP-1 receptors: Novel molecular targets for cocaine use disorder
2019, Physiology and BehaviorEffect of a 5-HT<inf>1D</inf> receptor agonist on the reinstatement phase of the conditioned place preference test and hippocampal long-term potentiation in methamphetamine-treated rats
2018, Brain ResearchCitation Excerpt :Human and animal studies have stated three retrospective main factors for relapse in drug abusers. These factors include stressors (Shaham and Stewart, 1994; Stewart, 2000), exposure to environmental (cues) stimuli that have been paired with drug use (Fuchs et al., 2008) and exposure to a single dose or priming drug (de Wit and Stewart, 1981; Gerber and Stretch, 1975). Administration of METH at 5 mg/kg induced a preference in the conditioning phase of the CPP in our study, which is consistent with a previous study (Shokrzadeh et al., 2015).
Animal Models of Addiction
2018, Neural Mechanisms of AddictionGabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats
2016, NeuropharmacologyCitation Excerpt :Therefore, a possible behavioral mechanism underlying the increase in alcohol self-administration may be related to drug priming. For example, in self-administration models, a priming injection of the self-administered drug or drugs with similar discriminative stimulus effects as the self-administered drug can potentiate (i.e., prime) drug-seeking behavior (Anker and Carroll, 2010; Dichiara and Reinhart, 1995, Fattore et al., 2003; Gerber and Stretch, 1975; De Wit and Stewart, 1981) and taking behavior (Norman et al., 1999; Mckee et al., 2009, O'malley et al., 2002, Brown et al., 2008). Such an explanation is supported by the discrimination assessments, in which gabapentin doses above 30 mg/kg had partial alcohol-like effects and potentiated the interoceptive effects of low alcohol doses.
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Supported by grant MT-3073 from the Medical Research Council of Canada to Dr. R. Stretch.
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We thank Andrea Gerber, Elizabeth Lane, and Les Schauss for technical assistance, and Drs. E. D. Olfert and F. M. Loew for veterinary services. Supplies of drugs were generously provided by Smith, Kline and French (d-amphetamine), May and Baker (cocaine and pentobarbital), and Poulenc (chlorpromazine).
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Reprints may be obtained from G. Gerber, Department of Psychology, Sir George Williams University, 1455 deMaisonneuve Blvd. W., Montreal, Quebec H3G 1M8, Canada.