Clinical Immunology and Immunopathology
Volume 52, Issue 2, August 1989, Pages 305-312
Regular articleEffects of cocaine on the immune system of Balb/C mice
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2013, Psychiatry ResearchCitation Excerpt :In addition, adults exposed to ELS seems to overreact in their emotional and physiological stress response and this could impact immune system. Regarding cocaine, chronic and acute use can induce protracted decreases in innate immune mechanisms interfering with autonomic activity in humans (Irwin et al., 2007) and have general suppressive effects on the mouse immune system (Ou et al., 1989). Moreover, in vivo experiments with the protozoan Tetrahymena, suggests that its phagocytic activity was decreased after the administration of cocaine, an effect that was more extensive after the administration of crack cocaine – very potent cocaine in pellet form that is smoked (Stefanidou et al., 2011).
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