PaperAntithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis
References (22)
- et al.
Heparin inhibits fibrin, but not leukocytes, in a model of deep-vein thrombosis
J Surg Res
(1987) - et al.
Anticoagulant and antithrombotic effects of heparin and low molecular weight heparin fragments in rabbits
Thromb Res
(1982) - et al.
The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin
Blood
(1985) - et al.
The effect of heparin fragments of different molecular weights on experimental thrombosis and haemostasis
Thromb Res
(1985) - et al.
Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis
Blood
(1977) - et al.
Characterization of recombinant tick anticoagulant peptide
J Biol Chem
(1990) - et al.
Effects of heparin, its low molecular weight fractions and other glycosaminoglycans on thrombus growth in vivo
Thromb Res
(1985) - et al.
Low molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis
Lancet
(1992) Thrombosis and Virchow's triad: what is established?
Sem Thromb Hemostas
(1989)Prevention of venous thrombosis and pulmonary embolism
JAMA
(1986)
Experimental studies on venous thrombosis: effect of coagulants, procoagulants and vessel contusion
Thromb Haemostas
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Exploring the anti-tumoral effects of tick saliva and derived components
2015, ToxiconCitation Excerpt :For example, the recombinant protein TAP (RTAP) of the Ornithodoros moubata tick has been tested in a variety of animal models for arterial and venous thrombosis. RTAP has shown greater efficacy without prolonged bleeding relative to traditional anticoagulants (Stoll et al., 2007; Fioravanti et al., 1993). The amblyomin-X protein from the saliva of Amblyomma cajennense ticks is an important candidate for anticancer therapy because of its cytotoxic effect on various tumors including pancreatic tumors and melanomas (which will be discussed later) (Simons et al., 2011).
Tick-derived Kunitz-type inhibitors as antihemostatic factors
2009, Insect Biochemistry and Molecular BiologyCitation Excerpt :Structure-and-function investigations of TAP range from thorough kinetic studies of FXa inhibition, including analysis of a large number of point and deletion mutants (Betz et al., 1997; Dunwiddie et al., 1992; Jordan et al., 1992, 1990; Krishnaswamy et al., 1994; Mao et al., 1995; Rezaie, 2004), determination of disulfide bonds and characterization of the folding pathway (Chang, 1996; Chang and Li, 2005; Chang et al., 2000; Sardana et al., 1991), as well as determination of its 3D structure, both unliganded and bound to the cognate proteinase (Antuch et al., 1994; Lim-Wilby et al., 1995; Wei et al., 1998). In addition, the antithrombotic potential of TAP has been assessed in a number of in vivo investigations (see e.g., refs. (Fioravanti et al., 1993; Ragosta et al., 1994; Schaffer et al., 1991; Sitko et al., 1992; Stoll et al., 2007)). Because of its rather low sequence homology to any other member of family I2, TAP has been classified within the same IB clan as Kunitz inhibitors, but as representative of a different family (I52).
Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031)
2002, Thrombosis ResearchAntithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals
2001, European Journal of Pharmacology