Elsevier

Thrombosis Research

Volume 28, Issue 5, 1 December 1982, Pages 607-616
Thrombosis Research

Paper
Acute arterial thrombosis in rabbits: Reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37,248-01)

https://doi.org/10.1016/0049-3848(82)90152-9Get rights and content

Abstract

Acute thrombosis was induced in the carotid arteries of anaesthetised rabbits by local electrical stimulation (1mA for 2 min) of the vessel wall. Histological findings confirmed the platelet-rich composition of the thrombus. Platelet accumulation at the stimulus site was quantitated with ‴'Indium-labelling of autologous platelets. In rabbits injected intravenously with either 2mg/kg dazoxiben or 10mg/kg aspirin, accumulation of labelled platelets was considerably reduced. Animals which received vehicle injection only, showed no such reduced thrombus formation. In separate experiments in anaesthetised rabbits, the levels of TxB2 and 6KPGF in clotting blood were measured in blood samples taken from animals which had received the above drug treatments. Aspirin markedly reduced the production of both arachidonate metabolites. In contrast, dazoxiben almost totally inhibited TxB2 production but caused a 3.5 fold increase in the levels of 6KPGF. These findings demonstrate an anti-thrombotic effect and confirm the mechanistic selectivity of a thromboxane synthetase inhibitor.

References (17)

There are more references available in the full text version of this article.

Cited by (14)

  • Novel platelet antiaggregating substances

    2001, Biochemical and Biophysical Research Communications
  • Laboratory monitoring of new antithrombotic drugs

    1994, Clinics in Laboratory Medicine
  • Hemostatic abnormalities in nephrotic syndrome

    1988, Veterinary Clinics of North America - Small Animal Practice
View all citing articles on Scopus
View full text