PaperLow dose aspirin and inhibition of thromboxane B2 production in healthy subjects
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Precision antiplatelet therapy
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2021, Pharmacological ResearchCitation Excerpt :First, we assessed whether the administration of this dose of Aspirin affected platelet COX-1 activity. As shown in Fig. 4E, in IPKO and WT mice fed with a high-salt diet, Aspirin profoundly inhibited the production of serum TXB2 (i.e., a capacity index of platelet COX-1 activity) [24] (93.8 ± 3 and 93.2 ± 3.5%, respectively). Aspirin also caused a marked reduction of the urinary levels of TXM (Fig. 4A) both in WT and IPKO mice fed with a high-salt diet.
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