Effect of halogenated hydrocarbon insecticides on the metabolism and uterotropic action of estrogens in rats and mice☆
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Examining the relationships between blubber steroid hormones and persistent organic pollutants in common bottlenose dolphins
2019, Environmental PollutionCitation Excerpt :Common bottlenose dolphins (Tursiops truncatus) and other toothed whales (odontocetes) bioaccumulate high concentrations of endocrine disrupting persistent organic pollutants (POPs) due to their high trophic position, long lifespan, and maintenance of extensive lipid reserves in blubber, which puts these species at risk to experience endocrine disruption (Colborn and Smolen, 1996). The organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyltrichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD; collectively referred to as DDTs), a class of POPs, disrupt vertebrate steroid hormone homeostasis by impairing adrenal, gonadal, and placental steroidogenesis (Hart and Straw, 1971; Hart et al., 1971; Jönsson et al., 1993; Lund et al., 1988; Wójtowicz et al., 2007a; Wójtowicz et al., 2007b); hepatic steroid metabolism (Balazs and Kupfer, 1966; Haake et al., 1987; Kupfer et al., 1964; Nowicki and Norman, 1972; Welch et al., 1967; Welch et al., 1971; You et al., 2001); steroid signaling through steroid receptor agonism and antagonism (Clark et al., 1998; Danzo, 1997; Kelce et al., 1995; Nelson et al., 1978; Oien et al., 1997); and steroid transport (Cocco et al., 2004; Nader et al., 2006; van Seters and Moolenaar, 1991). These effects vary by species and individual DDTs.
Assessing impacts of precocious steroid exposure on thyroid physiology and gene expression patterns in the American alligator (Alligator mississippiensis)
2019, General and Comparative EndocrinologyCitation Excerpt :Many persistent organic pollutants (POPs), including organochlorine pesticides (OCPs), are implicated as thyroid disruptors (Jefferies and French, 1972; Liu et al., 2011; Mayne et al., 2005; Richert and Prahlad, 1972), with their effects typically attributed to altering TH synthesis, metabolism, transport, and/or signaling (Liu et al., 2011), reviewed in (Brucker-Davis, 1998; Pearce and Braverman, 2009). OCPs also disrupt steroid hormone axes across vertebrate taxa through numerous mechanisms, including disruption of steroidogenesis in various tissues (Benguira and Hontela, 2000; Hart et al., 1971; Jonsson et al., 1994; Lund et al., 1988; Wójtowicz et al., 2007a,b; You et al., 2001), disruption of hepatic steroid metabolism (Balazs and Kupfer, 1966; Nowicki and Norman, 1972; Welch et al., 1967; Welch et al., 1971), and direct agonism/antagonism of steroid hormone receptors (Danzo, 1997; Kelce et al., 1995; Nelson et al., 1978; Oien et al., 1997). Importantly, the hypothalamo-pituitary-thyroid (HPT) axis is sensitive to steroid hormone signaling.
Human exposure to endocrine disrupting chemicals and fertility: A case-control study in male subfertility patients
2015, Environment InternationalCitation Excerpt :The negative association between exposure to chlorinated pesticides and fertility observed in this study is in accordance with data from the literature. Animal studies have shown that chlordane can interfere with the steroid receptor (Cassidy et al., 1994), possibly through induction of the cytochrome oxidase enzyme (Welch et al., 1971); persistent exposure to HCB adversely affected male fertility in mice and pigs, possibly through reduced testosterone levels or via direct histological changes in the testis (Toppari et al., 1996). To our knowledge, there are no human epidemiological studies reporting associations between chlordane or HCB and sperm quality.
Chlorpyrifos induced toxicity in reproductive organs of female Wistar rats
2013, Food and Chemical ToxicologyCitation Excerpt :The present study indicates a change in estrous cyclicity of rats after treatment with CPF and a state of prolonged metestrous which is characterized by a low level of estrogen was observed. The insecticide CPF has been found to show weak estrogenic activities (Welch et al., 1971; Orimo et al., 1999; Andersen et al., 2002). The estrogenic properties of CPF might have supplemented the low estrogen level to prolong the metestrous.
Metabolic Interactions of Pesticides
2012, Pesticide Biotransformation and Disposition, Third EditionPesticides and Hepatotoxicity
2010, Comprehensive Toxicology, Second Edition
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Supported in part by Research Contract PH 43-65-1066 from the Pharmacology-Toxicology Programs, National Institute of General Medical Sciences, National Institutes of Health.
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Present address: Department of Biochemistry, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.