Elsevier

Physiology & Behavior

Volume 15, Issue 6, December 1975, Pages 659-667
Physiology & Behavior

Effects of water deprivation, NaCl injection, and seven aversive taste stimuli on drinking in two normal mouse strains and one with diabetes insipidus

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Abstract

Water deprived SWR/J mice, with nephrogenic diabetes insipidus, lost more weitht and, subsequently, drank more water in a 60 min test period than did two normal strains, C3H/HeJ and C57BL/6J. An injection of 2 percent NaCl produced significant drinking in SWR/J mice, but not in the normal strains. In spite of the high water needs of the SWR/J strain, extreme finickiness was observed in a single-tube solution acceptance test when different solutions were offered, even though large weight losses and hyperosmolality of plasma accompanied abstinence from drinking. For the two normal strais, 3 different patterns of solution acceptance were seen for the 7 solution test which included sodium chloride, sodium acetate, potassium chloride, ethanol, hydrochloric acid, calcium chloride, and quinine hydrochloride.

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The authors are grateful for the technical assistance of Jeffrey Hamburger, Laura Peller, and William Wright in the performance of the experiment.

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