The quipazine- and YFMPP-increased conditioned avoidance response in rats: Role of 5-HT1C/5-HT2 receptors

doi:10.1016/0028-3908(93)90040-A

Neuropharmacology

Volume 32, Issue 12, December 1993, Pages 1427-1432

https://doi.org/10.1016/0028-3908(93)90040-A Get rights and content

Abstract

The role of serotonin (5-HT) in the acquisition of the conditioned avoidance response was investigated. The effects of different serotonin agonists and antagonists, administered prior to learning sessions, were studied in groups of naive rats using the two-way shuttle box. Quipazine, an agonist at 5-HT_1B/1C/2 receptors, significantly increased avoidance responding in a dose-dependent manner (1.25–10 mg/kg, s.c.). The putative 5-HT_1B/1C receptor agonist TFMPP (1-[m-trifluoromethylphenyl] piperazine) at doses of 1.25 and 2.5 mg/kg (s.c.), increased acquisition of conditioned avoidance but showed no significant difference from control at doses of 5 and 10 mg/kg. The 5-HT_1A agonist, buspirone, significantly decreased acquisition of conditioned avoidance. Increased acquisition of conditioned avoidance induced by either quipazine or TFMPP was effectively antagonized by the mixed 5-HT_1C/2 receptor antagonists, ketanserin (0.2 and 2 mg/kg, s.c.) and mianserin (1 mg/kg, s.c.). In contrast, spiperone (5-HT_1A/2 receptors antagonist: 0.2 mg/kg, s.c.) only inhibited the increased acquisition induced by TFMPP. On the other hand, the 5-HT_1A/1B receptors antagonist, pindolol, failed to antagonize the increase in acquisition of conditioned avoidance caused by quipazine or TFMPP. These results suggest that quipazine increases the conditioned avoidance behaviour by an action that might be mediated through stimulation of 5-HT_1C receptors. The acquisition of conditioned avoidance induced by TFMPP, which was blocked by ketanserin, mianserin and spiperone but not by pindolol, suggests the involvement of 5-HT_1C/2 receptors in the action of TFMPP.

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This article is part of a Special Issue entitled ‘Cognitive Enhancers’.

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The quipazine- and YFMPP-increased conditioned avoidance response in rats: Role of 5-HT1C/5-HT2 receptors

Abstract

Behav. Neural Biol.

Trends Pharmac. Sci.

Neuropharmacology

Life Sci.

Trends Pharmac. Sci.

Neurosci. Biobehav. Rev.

Neurosci. Biobehav. Rev.

Brain Res.

Eur. J. Pharmac.

Biol. Psychiat.

Neuropharmacology

The effect of neurotransmitters reuptake inhibition on conditioned avoidance responding

Res. Commun. Psychiat. Behav.

Evidence for excitatory 5-HT2 receptors on rat brain stem neurons

Br. J. Pharmac.

Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites

Naunyn-Schmiedebergs Arch. Pharmac.

Age-dependent effects of 5-hydroxytryptamine upon memory consolidation and central protein synthesis

Pharmac. Biochem. Behav.

Mechanism of the hypotensive effect of ketanserin

J. Cardiovasc. Pharmac.

The quipazine- and YFMPP-increased conditioned avoidance response in rats: Role of 5-HT_1C/5-HT₂ receptors

Evidence for excitatory 5-HT₂ receptors on rat brain stem neurons

Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT_1B binding sites