Nordihydroguaiaretic acid attenuates NMDA neurotoxicity—Action beyond the receptor
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Ring substitution influences oxidative cyclisation and reactive metabolite formation of nordihydroguaiaretic acid analogues
2015, Bioorganic and Medicinal ChemistryCitation Excerpt :NDGA is generally accepted as responsible for both beneficial and adverse effects associated with this shrub.2–6 NDGA shows promise in the treatment of multiple diseases, including cardiovascular diseases,7,8 neurological disorders9–13 and cancers.3,14–20 It also potently inhibits viruses such as human immunodeficiency virus (HIV-1), herpes simplex virus (HSV), human papilloma virus (HPV) and influenza virus.2,21
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2008, Critical Care ClinicsCitation Excerpt :Hypoxic conditions may further extend GLU activity as the absence of extracellular mechanism of degradation require the functioning of ATP-dependent reuptake, which is impaired under these conditions [226]. GLU is an excitatory neurotransmitter that may lead to neuronal injury via its activation of NMDA receptors [267–271]. Nevertheless, it appears that GLU requires the presence of DA to exert some of its toxic effects, namely its Ca2+-induced neuronal injury [219,221,223,228].
Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage
2006, Toxicology in VitroAstrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126
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