Role of serotonin and catecholamines in brain in the feeding suppressant effect of fluoxetine
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The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours
2018, Neurobiology of StressCitation Excerpt :Weight gain during the 19 day SD/OC component of the protocol was prevented by fluoxetine whilst CuII(atsm) attenuated it, a finding replicated across both trials. A number of studies have associated antidepressant treatment such as fluoxetine with inhibition of weight gain in humans (Halford et al., 2007; Li et al., 2005; Michelson et al., 1999; Serretti and Mandelli, 2010) and in rodents (Grignaschi and Samanin, 1992; Lightowler et al., 1996; Wong et al., 2005) however, the neurobiological processes behind these changes are not well understood (Kumar et al., 2013). Fluoxetine has been reported to decrease weight gain even in unstressed mice (Yen et al., 1987), and as such may have had direct effects on bodyweight in the present study that were independent of its anti-depressant properties.
Differential effects of chronic social stress and fluoxetine on meal patterns in mice
2013, AppetiteCitation Excerpt :Therefore, we wanted to determine if antidepressant treatment could reverse the effects of CSDS on food intake in this subpopulation of animals. We chose fluoxetine because it is a widely prescribed antidepressant and because several initial studies reported that fluoxetine suppresses food intake in rodents (Gamaro, Prediger, Lopes, Bassani, & Dalmaz, 2008; Grignaschi & Samanin, 1992; Lightowler et al., 1996; Wong, Reid, & Threlkeld, 1988), and human studies also suggest that fluoxetine acutely suppresses food intake (Serretti & Mandelli, 2010). For example, during a 1-year maintenance trial, fluoxetine treatment was associated with a modest initial weight loss during the first 4 weeks of treatment (Michelson et al., 1999).
Kindling epileptogenesis in immature rats leads to persistent depressive behavior
2007, Epilepsy and BehaviorCitation Excerpt :In contrast to saccharin, sucrose has caloric value. It is known that depression can be accompanied by both loss of and increase in appetite [21,27]; furthermore, antidepressant drugs, such as selective serotonin reuptake inhibitors, are commonly known to reduce appetite and curb weight gain [42–44]. Because the increase in taste preference in the sucrose test 4 weeks after kindling can be excluded based on the saccharin test, it is conceivable that the increased sucrose intake reflects increased appetite.
Effect of 5-HT in mianserin-pretreated rats on the structure of feeding behavior
2002, European NeuropsychopharmacologyNeurobiology of relapse to alcohol in rats
2002, Pharmacology and TherapeuticsCitation Excerpt :However, these data are not sufficient to conclude that 5-HT mechanisms are involved in relapse to alcohol. Specifically, the effects of SSRI agents on alcohol consumption and feeding behavior are not consistently altered by 5-HT receptor antagonists or by neurotoxic lesions of the serotonergic system (Amit et al., 1991; Grignaschi & Samanin, 1992). In addition, recent data suggest that activation of 5-HT3 receptors may be involved in the ADE.
Meal patterning in rodents: Psychopharmacological and neuroanatomical studies
2000, Neuroscience and Biobehavioral Reviews