Elsevier

Neuropharmacology

Volume 31, Issue 5, May 1992, Pages 445-449
Neuropharmacology

Role of serotonin and catecholamines in brain in the feeding suppressant effect of fluoxetine

https://doi.org/10.1016/0028-3908(92)90082-ZGet rights and content

Abstract

The hypophagic effect of fluoxetine was studied in rats, injected intracerebroventricularly with 150 μg/20μl 5,7-dihydroxytryptamine, to destroy serotonin-containing neurones or 250 μg/20μl 6-hydroxydopamine, to destroy catecholamine-containing neurones. The effect of various serotonin receptor antagonists was assessed as well. Neither neurotoxin significantly modified the effect of 20 mg/kg (i.p.) fluoxetine on food intake. Metergoline (1–5 mg/kg), (−)-propranolol (16 mg/kg) and ICS 205–930 (0.1 and 1 mg/kg) did not modify the hypophagic effect of fluoxetine, while mianserin (1 and 5 mg/kg), ritanserin (0.5 and 1 mg/kg) and xylamidine (3 mg/kg) slightly but significantly reduced it. While the mechanism by which some 5-HT receptor antagonists modify the effect of fluoxetine remains to be elucidated, it seems clear that 5-HT receptors hardly have any significant role in the ability of the drug to suppress food intake.

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