Selective serotonin1A/1B agonists differentially affect spinal nociceptive reflexes
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Cited by (46)
Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model
2018, Pharmacological ReportsCitation Excerpt :However, 5-HT modulates spinal nociceptive transmission in a complex manner, employing the involvement of multiple 5-HT receptor subtypes and their specific localization in the CNS [23]. 5-HT1 family receptors are present in the whole spinal cord and in the grey matter in all the areas examined, and it is the major class of 5-HT receptor found in the dorsal horn [24,25]. Eide et al. [26] examined whether the administration of 5-HT1A and 5-HT1B receptor agonists in mice could alter the tail-flick reflex and whether the effects on reflex latency involve changes in tail-skin temperature; the authors found that in the mouse, both 5-HT1A and 5-HT1B receptor agonists inhibit the nociceptive tail-flick reflex when injected into the spinal subarachnoid space, and that the effect does not depend on changes in tail-skin temperature.
Comparison of operant escape and reflex tests of nociceptive sensitivity
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The excitability of motoneurons and associated interneurons in the ventral horn strongly influences frequencies, latencies, amplitudes and durations of flexion, withdrawal and guarding responses to nociceptive input (Schomburg and Steffens, 1998). Flexion/withdrawal/guarding reflexes are preserved caudal to a spinal transection (Advokat, 2002; Kauppila, 1998; Murphy and Zemlan, 1990) and therefore are referred to as spinal reflexes. However, reflex tests cannot be considered to represent spinal processing of pain sensations.
Pronociceptive effect of 5-HT<inf>1A</inf> receptor agonist on visceral pain involves spinal N-methyl-d-aspartate (NMDA) receptor
2012, NeuroscienceCitation Excerpt :It is well recognized that 5-HT1A plays an important role in pain modulation. However, the existing reports are conflicting as in some studies 5-HT1A receptor agonist produced antinociception (Eide et al., 1988; El-Yassir et al., 1988; Eide and Hole 1991, 1993; Xu et al., 1994; Gjerstad et al., 1996; Millan et al., 1996; Oyama et al., 1996), pronociception (Solomon and Gebhart, 1988; Zemlan et al., 1988; Murphy and Zemlan, 1990; Crisp et al., 1991a,b; Alhaider and Wilcox, 1993; Ali et al., 1994; Zhang et al., 2001) or no effect (Millan and Colpaert, 1990; Mjellem et al., 1992; Millan et al., 1996; Bardin et al., 2000). Although the reason for such a diverse effect of 5-HT1A agonist is not clearly known, it is speculated that the effect of 5-HT1A agonist can be variable depending on the type of pain model, pathological conditions, route of administration, and species.
Inhibition of opioid release in the rat spinal cord by serotonin 5-HT<inf>1A</inf> receptors
2007, Brain ResearchCitation Excerpt :By inhibiting spinal opioid release, 5-HT1A receptors would decrease opioid-mediated analgesia, resulting in an overall pro-algesic effect. Previous studies on the effect of 5-HT1A receptors on pain responses have provided conflicting results, including both analgesic (Danzebrink and Gebhart, 1991; Eide et al., 1990; el-Yassir et al., 1988; el-Yassir and Fleetwood-Walker, 1990; Gjerstad et al., 1996; Oyama et al., 1996; Xu et al., 1994) and hyperalgesic effects (Alhaider and Wilcox, 1993; Ali et al., 1994; Crisp et al., 1991; Murphy and Zemlan, 1990; Solomon and Gebhart, 1988; Zemlan et al., 1988). Therefore, it is likely that 5-HT1A receptors produce multiple actions in the spinal cord with opposite results on pain modulation.