Mechanisms of the inhibition of fast axonal transport by local anesthetics
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Effect of Pulsed Radiofrequency Treatment on the Thoracic Medial Branch for Managing Chronic Thoracic Facet Joint Pain Refractory to Medial Branch Block with Local Anesthetics
2018, World NeurosurgeryCitation Excerpt :Although debates regarding the therapeutic benefit of MBB with local anesthetics exist, several studies showed its long-acting pain relief effect in TFJ pain.6,11,12 The postulated mechanisms of the pain-reducing effect of local anesthetics include the suppression of nociceptive discharge, blockade of axonal transport, blockade of the sympathetic reflex arc and sensitization, and anti-inflammatory effects.34-38 In this study, the author included only patients who were unresponsive to therapeutic MBB with local anesthetics.
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Copyright © 1989 Published by Elsevier Ltd.