Effect of morphine and morphine-like analgesics on susceptibility to seizures in mice
References (17)
- et al.
Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat
Eur. J. Pharmac.
(1983) - et al.
Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat
Eur. J. Pharmac.
(1984) Pro- and anticonvulsant actions of morphine and the endogenous opioids: Involvement and interactions of multiple opiate and non-opiate systems
Brain Res. Rev.
(1983)- et al.
Similar anticonvulsant, but unique behavioural effects of opioid agonists in the seizure-sensitive Mongolian gerbil
Newropharmacology
(1984) - et al.
Opiate receptor phenomenon: Proconvulsant action of morphine in the mouse
Life Sci.
(1974) - et al.
Morphine responsiveness and seizure proneness
Expl Neurol.
(1984) - et al.
Studies on the excitatory and inhibitory influence of intra-cerebroventricularly injected opioids on seizure thresholds in rats
Neuropharmacology
(1984) - et al.
Anticonvulsant action of acute morphine administration in rats
J. Pharmac. exp. Ther.
(1976)
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2016, Journal of Neuroscience MethodsCitation Excerpt :In contrast, the amygdala kindling model does not show enhanced response to general anaesthesia (Long et al., 2009). There are indications that certain analgesic drugs (e.g. neuroleptics and opioids) have an effect on seizure susceptibility and expression (Czuczwar and Frey, 1986; Hashem and Frey, 1988). Pharmacokinetic and pharmacodynamic factors need to be considered with co-administration of drugs.
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2013, Oral and Maxillofacial Surgery Clinics of North AmericaAnticonvulsant effects of agomelatine in mice
2012, Epilepsy and BehaviorCitation Excerpt :The onset of tonic convulsion and the number of animals convulsing or not convulsing within the observation period were noted. Agomelatine's ability to prevent or delay the onset of the hindlimb extension exhibited by the animals was taken as an indication of anticonvulsant activity [9–12]. All experiments were carried out between 8:40 a.m. and 4:00 p.m. in a quiet room with room temperature of 22 ± 1 °C.
Anticonvulsant action of Calotropis procera latex proteins
2012, Epilepsy and BehaviorCitation Excerpt :They were then placed in individual cages and observed for 30 minutes. Latency to the first convulsion, percentage of animals exhibiting convulsions, latency to death, and percentage of deaths were the parameters measured [15,16]. Mice that did not show clonic or tonic convulsions within 30 minutes of strychnine, pilocarpine, or PTZ administration were considered protected.
Central action of Araucaria angustifolia seed lectin in mice
2009, Epilepsy and BehaviorCitation Excerpt :Animals were treated with lectin (0.1, 1.0, or 10.0 mg/kg, ip) or saline (control, ip) 30 min before administration of PTZ (85 mg/kg, ip), pilocarpine (400 mg/kg, sc), or strychnine (75 mg/kg, ip), placed in individual cages, and observed for 60 min. The parameters measured were: latency to the first convulsion or death, percentage of animals convulsing, and percentage of animals surviving [9,10]. Animals were treated with saline (control, ip), lectin (0.1, 1, or 10 mg/kg, ip), diazepam (1 mg/kg, ip), flumazenil (1 mg/kg, ip), flumazenil (1 mg/kg, ip) followed 15 min later by lectin (10 mg/kg, ip), or flumazenil (1 mg/kg, ip) followed 15 min later by diazepam (1 mg/kg, ip).