Elsevier

Neuropharmacology

Volume 9, Issue 1, January 1970, Pages 9-16
Neuropharmacology

Comparative effects of nicotine and amphetamine on timing behavior in rats

https://doi.org/10.1016/0028-3908(70)90043-2Get rights and content

Abstract

The effects of nicotine (0.05, 0.1, 0.2 and 0.3 mg/kg; base) and amphetamine (0.2, 0.4 and 0.8 mg/kg; base) were tested on the timing behavior in rats. Both the drugs caused an increase in the number of responses and a decrease in reinforcement, and thus disrupted the timing behavior. No consistent delayed effect was observed with these doses. In case of both the drugs, a rough dose-effect relation could be demonstrated, and the inter-response time distributions were found to be shifted to the shorter class intervals, consistent increase occurring in the intermediate interval group.

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This investigation was supported by a grant from the Council of Tobacco Research, U.S.A. and the Public Health Service Research Grant No. UI-00472 from the National Center for Urban and Industrial Health.

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