Carbohydrate-fat exchange and regulation of hepatic cholesterol and plasma lipoprotein metabolism in the guinea pig☆
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Cited by (24)
Effect of fish meal replacement by black Soldier Fly (Hermetia illucens) larvae meal on serum biochemical indices, thyroid hormone and zootechnical performance of laying chickens
2022, Journal of Applied Poultry ResearchCitation Excerpt :The increase in these parameters in our studies could probably be related to the fat content of the larvae meal compared to fish meal (Kroeckel et al., 2012). Studies in guinea pigs have shown that increasing the lipid content of the diet altered the composition of plasma lipoproteins, notably by increasing the proportion of cholesterol esters in VLDL, LDL, and HDL, which are associated with an increase in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, an enzyme involved in cholesterol synthesis (Fernandez and Mc Namara, 1991; Fernandez et al., 1995). These results corroborate those obtained by Dabbou et al. (2018) who found a low total cholesterol and triglycerides concentration with increasing defatted larvae meal in broiler diets.
Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol diet
2010, AtherosclerosisCitation Excerpt :The use of surrogates for atherosclerosis is advantageous because animals can reach hard endpoints in a short period of time with a reduced cost and target tissues can be collected for analyses. Guinea pigs have been successfully used to study the effects of both LCD and low-fat diet (LFD) [8,9]. In addition, it is possible to quickly induce the initial stages of atherosclerosis by feeding them high levels of cholesterol [10,11].
Corn husk oil lowers plasma LDL cholesterol concentrations by decreasing cholesterol absorption and altering hepatic cholesterol metabolism in guinea pigs
2000, Journal of Nutritional Biochemistry
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Supported by a Grant-in-Aid from the American Heart Association, Arizona Affiliate, Tempe, AZ.