Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice
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New Advances in Histamine Research
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Cited by (83)
Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats
2021, Behavioural Brain ResearchCitation Excerpt :Similar to the results observed for E177 in STPAP, H3R E177 (5 and 10 mg/kg) mitigated the PTZ-induced memory deficits in EPMP, and no significant difference was detected between the two doses of test compound. Notably, ameliorative effects of the imidazole-based H3R antagonist, namely thioperamide, on memory impairment associated with scopolamine-induced learning deficits following in EPMP in mice was previously described [56]. Interestingly and in the current study, acute systemic pretreatment with the reference drug VPA (300 mg/kg) significantly attenuated the PTZ-induced memory impairment in both behavioral paradigms, namely STPAP and EPMP tasks.
Neuronal histamine and cognitive symptoms in Alzheimer's disease
2016, NeuropharmacologyMechanism of the histamine H<inf>3</inf> receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice
2014, NeuropharmacologyCitation Excerpt :Because of its roles in the central nervous system (CNS), H3R, a Gi/o-coupled receptor, has specially captured the interest of many researchers in recent years (Barbier et al., 2004; Motawaj et al., 2011; Passani et al., 2007; Toyota et al., 2002). Particularly, the prototype H3R antagonist thioperamide has been extensively used since it was first introduced in 1987 (Arrang et al., 1987), revealing the various functions of H3R (Clapham and Kilpatrick, 1994; Ghi et al., 1998; Hew et al., 1990; Imaizumi and Onodera, 1993; Jia et al., 2006; Komater et al., 2005; Miyazaki et al., 1994; Mochizuki et al., 1991; Sakai et al., 1991). H3R activation inhibits histaminergic neurotransmission by reducing the firing of histaminergic neurons in the tuberomamillary nucleus and by inhibiting histamine synthesis and release (Arrang et al., 1983).
Early cognitive changes due to whole body γ-irradiation: A behavioral and diffusion tensor imaging study in mice
2013, Experimental NeurologyReduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats
2013, Brain Research BulletinCitation Excerpt :Studies have also shown that intracerebroventricular injection of histamine facilitates olfactory social memory tasks, while the opposite effect was found by lowering central histamine (Argyriou et al., 1997). Furthermore, activation of H1R has been shown to prevent muscarinic M1 receptor blocker (scopolamine) induced memory deficits (Miyazaki et al., 1995). The finding by this study of reduced H1R binding density in the Pir, suggests a possible deficit or reduced function in olfactory memory tasks caused by high-fat diet, which needs further investigation.
SAR110894, a potent histamine H<inf>3</inf>-receptor antagonist, displays procognitive effects in rodents
2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :In this study, SAR110894 prevented the occurrence of episodic memory deficit induced by scopolamine in the object recognition test in rats. Several H3-R antagonists have been shown to be active in models of scopolamine-induced cognitive deficits, including passive avoidance, object recognition and delayed non-matching to position (DNMTP) tests (Galici et al., 2009; Ligneau et al., 2007; Medhurst et al., 2007; Miyazaki et al., 1995a, 1995b; Molinengo et al., 1999). Interestingly, in the study using DNMTP, the antagonism of scopolamine effects was associated with normalization of ACh neurotransmission in the cortex.