Pharmacology letter accelerated communicationAntagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of μ1-opioid receptors
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2005, Journal of Pain and Symptom ManagementCitation Excerpt :Buprenorphine is a partial μ-opioid receptor agonist and kappa-opioid receptor agonist, but most of its antinociceptive activity is exercised through μ1 opioid receptors.11 Buprenorphine may attenuate effects of other opioids like morphine,12 acting as a competitive inhibitor to other, endogenous opioids. Our patient responded promptly to buprenorphine, but again, the effect was short lasting, so the dose frequency needed to be increased.
Agonist and antagonist properties of dihydroetorphine for μ-opioid receptors in mice
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