Anticonvulsant effects of intracerebroventricularly administered norepinephrine are potentiated in the presence of monoamine oxidase inhibition in severe seizure genetically epilepsy-prone rats (GEPR-9s)
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Quantitative serum proteome analysis using tandem mass tags in dogs with epilepsy
2024, Journal of ProteomicsThe role of monoaminergic neurons in modulating respiration during sleep and the connection with SUDEP
2022, Biomedicine and PharmacotherapyCitation Excerpt :Multiple studies have confirmed that the NE system has an inhibitory effect on epilepsy [152–154], and this protective effect of NE is mediated by adrenergic α1 receptors related to respiratory regulation [155]. For example, in animal experiments, implantation of LC tissue into rats lacking central catecholamine neurons could delay the development or diffusion of epileptic activity [156], and congenital defects of the NE system were shown to be a determinant of epilepsy susceptibility and severity in GEPRs [157]. In a clinical study, the density of adrenergic α1 receptors was decreased in patients with refractory partial epilepsy [158], and activation of the LC in epilepsy patients could reduce the incidence and severity of seizures [159].
Effects of AT<inf>1</inf> receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats
2015, Epilepsy and BehaviorCitation Excerpt :Extensive evidence supports the regulatory role of NADergic neurotransmission in the control of seizure susceptibility, including seizure propagation in the limbic structures [52,53]. Genetically epilepsy-prone rats (GEPR), in which the NADergic system has been disturbed, are more sensitive to experimentally evoked seizures, and restoration of NADergic activity has been shown to attenuate the enhanced seizure susceptibility [54,55]. Moreover, activation of the locus coeruleus NADergic system [56] and hippocampal NAD reuptake inhibition [57] is able to alleviate seizure activity induced by chemoconvulsants.
The role of the central noradrenergic system in behavioral inhibition
2011, Brain Research ReviewsCitation Excerpt :While these correlations may, in fact, reflect the role of the noradrenergic system in sensory regulation or decision processes, it is also possible that they function to inhibit the excessive spread of neural activation during these arousing conditions. Exogenous NE and the noradrenergic system have been established to have potent anti-seizure properties that are mediated by primarily by α1-adrenoceptors in forebrain areas (Ko et al., 1984; Mishra et al., 1993; 1994; Weinshenker et al., 2001; Yan et al., 1998) and possibly also via the release of galanin (Lerner et al., 2008). The activation of this system may function, therefore, to quell this activity throughout the forebrain.
The role of norepinephrine in epilepsy: From the bench to the bedside
2004, Neuroscience and Biobehavioral ReviewsThe role of catecholamines in seizure susceptibility: New results using genetically engineered mice
2002, Pharmacology and Therapeutics