P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
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Drug Delivery to the Brain: Pharmacokinetic Concepts
2017, Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain BarrierQuantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics
2015, Journal of Pharmaceutical SciencesCitation Excerpt :Among SLC transporters, GLUT1, monocarboxylate transporter 1 (MCT1/SLC16A1), fatty acid transport protein 1 (FATP1/SLC27A1), ATA2, and OATP3A1 were quantified, and GLUT1 exhibited the greatest expression among them in all fractions (Table 2). The luminal (fL) and abluminal distribution ratios (fA) were calculated to investigate the membrane localization of transporters in porcine brain capillary endothelial cells, employing MDR1 and ATA2 as luminal and abluminal marker proteins, respectively.3,4,7 Among all quantified molecules, MDR1 showed the greatest fraction distribution ratio (0.388) in fraction #1, and ATA2 showed the greatest ratio (0.517) in fraction #4, without correction for cross-contamination.
Pharmacokinetic Concepts in Brain Drug Delivery
2022, AAPS Advances in the Pharmaceutical Sciences Series
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