Ethanol and diolein stimulate PKC translocation in astroglial cells
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Cited by (48)
Estradiol protects against alteration of protein kinase Cε in a binge model of ethanol dependence and withdrawal
2005, European Journal of PharmacologyCitation Excerpt :Exact mechanisms underlying PKCɛ-activation depending upon its translocation sites are not well understood. Nonetheless, a majority of studies agree with our findings such that ethanol exposure and ethanol withdrawal increased membrane translocation of PKCɛ (Solem et al., 2000; Zhou et al., 2002) or total PKC (Skwish and Shain, 1990; DePetrillo and Liou, 1993). Both ethanol exposure and ethanol withdrawal increased membrane translocation and membrane protein levels but only ethanol withdrawal enhanced activity of PKC.
Ethanol modulates nicotine-induced upregulation of nAChRs
2003, Brain ResearchCitation Excerpt :We also postulated that the initial decrease in receptor expression caused by exposure to ethanol alone may be due to an increase in the percentage of cells in an active state and subsequent downregulation. Ethanol can activate PKC in acute exposure paradigms [11,20,39] and we proposed that by blocking PKC activity, we may be able to prevent the downregulation produced by 24 h of ethanol exposure. Fig. 5B shows that chelerythrine, a PKC inhibitor, prevents the downregulation normally seen at this time point.
Chapter 7 Changes in gene expression and signal transduction following ibogaine treatment
2001, Alkaloids: Chemistry and BiologyInhibition of astroglial cell proliferation by alcohols: Interference with the protein kinase C-phospholipase D signaling pathway
2000, International Journal of Developmental NeuroscienceCitation Excerpt :Thus, ethanol may have acted directly on PKC or on downstream targets of PKC activation. With respect to PKC, some data indicate a stimulating role of ethanol on PKC translocation; [32] however, in astrocytes, ethanol and the butanols did not affect the PDB-induced translocation of PKCα to membranes (Jin and Klein, unpublished observations). Recent work by Slater and colleagues demonstrated that ethanol and other primary alcohols inhibit PKC activity in a lipid-free in vitro assay acting at an alcohol binding site [33,34].
Ethanol-induced effects on expression level, activity, and distribution of protein kinase C isoforms in rat liver Golgi apparatus
1998, Chemico-Biological Interactions