Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease
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2015, Pharmacological ResearchCitation Excerpt :Tacrine can inhibit MAO-A and to a lesser extent MAO-B [24]. Uptake of dopamine, norepinephrine, and serotonin are also inhibited by micromolar concentrations of tacrine [25,26]. These effects appear to increase brain levels of monoamines and contribute to therapeutic actions of tacrine.
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones
2010, European Journal of Medicinal ChemistryCitation Excerpt :However, the use of tacrine in AD has been limited by serious side effects such as hepatotoxicity, which often forces patients to discontinue treatment [11–14]. Tacrine has also been shown to possess a much broader pharmacological profile than cholinesterase inhibition: blockage of potassium channels [15,16], inhibition of the neuronal monoamine uptake processes [17,18], and inhibition of monoamine oxidase [19], have all been reported. An important contribution to the development of tacrine related agents showed that tacrin-1-ol (1b, velnacrine) [20], an active metabolite of tacrine, has been chosen for clinical trial.
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