Elsevier

Life Sciences

Volume 38, Issue 17, 28 April 1986, Pages 1565-1571
Life Sciences

Renal effects of SK&F 82526 in anesthetized rats

https://doi.org/10.1016/0024-3205(86)90495-9Get rights and content

Abstract

Dopamine affects renal hemodynamics, renal tubular functions, and the secretion of renin. We have studied the renal effects of SK&F 82526 (an agonist which is selective for the DA1 subclass of dopamine receptors) in anesthetized rats. Infused intravenously at 0.005 μmol/min/kg, this drug increased renal plasma flow and the clearances of PAH and inulin, effects which are consistent with decreased renovascular resistance. Concomitantly, urine flow and K excretion increased, and Na excretion tended to increase. All these effects of SK&F 82526 were antagonized by intravenous metoclopramide (1 μmol/min/kg). Despite its diuretic effect and despite its lack of effect on arterial blood pressure, SK&F 82526 increased arterial plasma renin concentration, suggesting a stimulatory effect on renin secretory rate. Taken together, our results demonstrate that the renal effects of SK&F 82526 mimic those of dopamine.

References (18)

  • T. Nakajima et al.

    Jap. J. Pharmac.

    (1980)
  • O.-E. Brodde

    Life Sci.

    (1982)
  • J.-L. Imbs et al.

    Eur. J. Pharmac.

    (1975)
  • P.C. Churchill et al.

    Kidney Int.

    (1973)
  • R.J. Dinerstein et al.

    Science

    (1979)
  • C. Bell et al.

    J. Neurochem.

    (1978)
  • H. Mizoguchi et al.

    Am. J. Physiol.

    (1983)
  • R.A. Hahn et al.

    J. Pharmac. Exp. Therap.

    (1982)
  • D.M. Ackerman et al.
There are more references available in the full text version of this article.

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