A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain
References (36)
- et al.
Pharmacol. Biochem. Behav.
(1982) - et al.
Life Sci.
(1985) - et al.
Life Sci.
(1985) - et al.
- et al.
Pain
(1977) - et al.
Life Sci.
(1983) - et al.
Brain Res.
(1984) - et al.
Life Sci.
(1980) - et al.
Life Sci.
(1983) Neuropharmacol.
(1982)
Neuropharmac.
J. Pharmacol. Exp. Ther.
Ann. Rev. Neurosci.
J. Pharmacol. Exp. Ther.
Life Sci.
Br. J. Pharmacol.
J. Pharmacol. Exp. ther.
Cited by (44)
Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system
2020, Pharmacology Biochemistry and BehaviorCitation Excerpt :Candidate areas for such direct interaction would be the VTA and nucleus accumbens (NAcc), regions where the μ opioid receptor has been shown to mediate the rewarding and reinforcing properties of alcohol as well as other rewarding substances (Cowen and Lawrence, 1999; Herz, 1997; Marinelli et al., 2003; Pecina and Berridge, 2005; Spanagel et al., 1992; Tanda and Di Chiara, 1998; Uhari-Vaananen et al., 2016; Weiss et al., 1993; Zhang and Kelley, 2002). Even though morphine and naltrexone, the opioid ligands used in this study, are not selective for one subtype of opioid receptor, they preferentially bind μ, over κ and δ opioid receptors (Abbott et al., 1986; Altshuler et al., 1980; Gonzales and Weiss, 1998). Therefore, it can be speculated that, in the presence of both a Sig-R agonists, such as DTG, and morphine, the μ-induced GPCR activation would be reduced, resulting in a decreased dopamine signaling.
Effects of plant-derived analgesic compounds sinomenine and salvinorin A in infant rats
2020, Journal of Integrative MedicineCitation Excerpt :Alternatively, other neural sites, such as the spinal cord dorsal horn, may mediate sinomenine’s effects. In adult rodents, activation of MRGPRX2 receptors [43–46] is analgesic. We know of no data on the maturation of this receptor or its ligand but from our the data in this current study, sinomenine as an effective analgesic is late maturing.
Amniotic-fluid ingestion enhances central δ-opioid-induced hypoalgesia in rats in the cold-water tail-flick assay in a repeated-measures design
2018, Brain ResearchCitation Excerpt :However, several studies have also shown that algesiometric tests that rely on heat as a stimulus, such as the hot-water tail-flick, radiant-heat tail-flick, and the hot-plate assays have two main limitations: (a) they are not equally sensitive to all opioid agonist species in all routes of administration; and (b) they are not amenable to repeated-testing designs. As to the first limitation, the assays have differential sensitivities across the range of opioid agonists and partial agonists with heat-based assays showing the greatest sensitivity and range of measurement for µ-opioid mediated effects and the least for κ-induced antinociception (Abbott et al., 1986; Adams et al., 1993; Hayes et al., 1987; Leighton et al., 1987; Shaw et al., 1988; Tyers, 1980). In regard to the second limitation – that of repeated-testing effects – assays like the hot plate, radiant heat tail-flick, and the hot-water tail-flick have shown repeated-exposure effects that result in a gradual decrease in baseline latency measurements when retesting the same subjects.
The role of descending fibers from the rostral ventromedial medulla in opioid analgesia in rats
2002, European Journal of Pharmacology