MinireviewGlutathione; Metabolism and function via the γ-glutamyl cycle
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Cited by (120)
Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol
2022, Analytical BiochemistryCitation Excerpt :Cytosolic and microsomal epoxide hydrolases (EH) are detoxifying enzymes that specifically metabolize epoxides [25]. GSH is formed in the γ-glutamyl cycle (Fig. S7) and is provided as a cofactor/substrate for various reactions including those catalyzed by GST [26,27]. Several diseases are associated with specific enzyme deficiencies of the γ-glutamyl cycle [28].
The anti-aging effect of Scutellaria baicalensis Georgi flowers extract by regulating the glutamine-glutamate metabolic pathway in D-galactose induced aging rats
2020, Experimental GerontologyCitation Excerpt :The GSH synthesis involves the combination of cysteine with glutamate to produce γ-glutamylcysteine catalyzed by the enzyme GCL. The next step involves the enzyme glutathione synthetase (GSS), responsible for adding glycine to the dipeptide to produce GSH (Meister, 1974). Studies have found that overexpression of GSS doesn't increase GSH activity, while overexpression of GCL can increase GSH activity.
Ras Downstream Effector GGCT Alleviates Oncogenic Stress
2019, iScienceCitation Excerpt :Extracellular GSH can be hydrolyzed by membrane-bound γ-glutamyl transpeptidase (GGT) to cysteinylglycine and γ-glutamyl-amino acid dipeptide (Anderson, 1998; Meister, 1988). In the cytoplasm, γ-glutamyl cyclotransferase cleaves the γ-glutamyl-amino acid to give 5-oxoproline and amino acid (Meister, 1974). However, the function of GGCT (C7orf24) in GSH homeostasis is still unknown.
Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages
2017, Free Radical Biology and MedicineCitation Excerpt :The de novo GSH biosynthesis is mainly regulated through glutamate cysteine ligase (GCL), the rate-limiting enzyme in the biosynthesis reaction. GCL activity is determined by several factors including the absolute protein levels of both its catalytic subunit (GCLC) and modifier subunit (GCLM) [15,16], the ratio of GCLC/GCLM [17], and the feedback inhibition of GCL by GSH itself [18]. Studies from past decades have demonstrated that the expression of both GCLC and GCLM subunits could be induced in response to oxidative stress, through nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling [16,19–22].
Enlightening the Mechanism of Ferroptosis in Epileptic Heart
2024, Current Medicinal ChemistryLysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity
2023, Nature Communications