Influence of active and passive immunity on the disposition of dihydromorphine-H3

doi:10.1016/0024-3205(74)90016-2

Life Sciences

Volume 15, Issue 5, 1 September 1974, Pages 1017-1028

https://doi.org/10.1016/0024-3205(74)90016-2 Get rights and content

Abstract

The effect of circulating antibodies on the plasma and brain concentration of dihydromorphine-³H was examined. Rabbits immunized with the morphine antigen 3-0-carboxymethyl morphine coupled to bovine serum albumin served as the source of the antibodies which were used for passive immunization of mice and rats. The 45 minute plasma concentration of the narcotic was increased 90–100 fold in passively immunized animals whereas the brain concentration decreased by at least 75 percent. Mice were also actively immunized with the morphine antigen. Compared to non-immunized mice, plasma levels of dihydromorphine-³H were increased in the immunized mice from 7–30 fold at all intervals measured for at least 4 days. The plasma half life was markedly slowed in immunized mice. The narcotic bound to the antibody in the plasma $in vivo$ could be displaced by the administration of morphine. The consequence of active immunization on brain narcotic content varied with the dose of the drug and time interval studied. We suggest the possibility that the antibodies may initially act to sequester the narcotic but with time as the narcotic is slowly released from the antibodies that they may also act as a circulating source of the drug. It is apparent that the presence of circulating antibodies can have marked effects on the disposition of narcotics.

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Citation Excerpt :
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Influence of active and passive immunity on the disposition of dihydromorphine-H3

Abstract

U.S. Public Health Service Rep.

J. Lab. Clin. Med.

Science

Influence of active and passive immunity on the disposition of dihydromorphine-H³