Mast cells in brains during experimental allergic encephalomyelitis in Lewis rats

doi:10.1016/0022-510X(91)90136-U

Journal of the Neurological Sciences

Volume 105, Issue 2, October 1991, Pages 135-142

https://doi.org/10.1016/0022-510X(91)90136-U Get rights and content

Abstract

We studied the number of mast cells and their extent of degranulation in brains of Lewis rats with acute experimental allergic encephalomyelitis (EAE), actively induced with guinea pig spinal cord and Freund's complete adjuvant. Non-immunized controls and EAE rats were killed on days 10, 11, 12, and 16 post-immunization (p.i.). The percentage of degranulated mast cells was significantly increased in EAE brains. Signs of degranulation were observed as early as day 10 p.i. Clinical EAE signs appeared from day 10 p.i. A significant change in mast cell number was not observed. The percentage of degranulated cells was largest at day 16 p.i., at a time when the inflammation had reached the thalamus. This indicates that mast cell degranulation may occur as a result of the inflammation. Collectively, the data suggest that mast cells may play a role in the pathogenesis of EAE.

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Research paperMast cells in brains during experimental allergic encephalomyelitis in Lewis rats

Abstract

Brain Res.

Cell. Immunol.

Brain Res.

Cell. Immunol.

Int. Rev. Cytol

J. Neuroimmunol.

J. Neuroimmunol.

Cell. Immunol.

Life Sci.

Biochem. Pharmacol.

J. Neuroimmunol.

J. Neuroimmunol.

Delayed type hypersensitivity: activation of mast cells by antigen specific T-cell factors initiates the cascade of cellular interactions

Immunol. Today

Differential release of histamine and eicosanoids- from human skin mast cells activated by IgE-dependent and non-immunological stimuli

Br. J. Pharmacol.

Delayed onset of experimental allergic neuritis in rats treated with reserpine

J. Neuropathol. Exp. Neurol.

Quantitation of mast cells in experimental allergic neuritis

J. Neuropathol. Exp. Neurol.

Evidence for immediate hypersensitivity phenomena in experimental allergic uveoretinitis

Eur. J. Immunol.

Research paper
Mast cells in brains during experimental allergic encephalomyelitis in Lewis rats