Long-acting estrogenic responses of estradiol fatty acid esters
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2011, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :The authors speculated that clofibrate might have potentiated the estrogenic effect of estradiol on the mammary gland by enhancing the hydrolysis of estradiol fatty acid esters in the surrounding fatty tissues [30]. Early studies have indicated that, when injected parenterally, estradiol 17-esters are metabolized more slowly than nonesterified estradiol leading to an increased duration of the estrogenic signal [31–33]. More recently, Paris et al. observed that also orally administered estradiol 17-stearate was more slowly metabolized and induced a stronger uterotrophic effect than unesterified estradiol in juvenile female rats [34].
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